Pre-Clinical Modeling and Simulation of Radiofrequency Ablation in Human Lung Tumor
Journal Title: International Journal of Mechanical and Production Engineering Research and Development (IJMPERD ) - Year 2017, Vol 7, Issue 4
Abstract
Radio-frequency ablation (RFA) is a hyperthermia medical treatment modality, used to destroy the unwanted tissues in the human body. In this article, pre-clinical computational model has been demonstrated for attaining risk frees RFA of lung tumor. The objective of this study is, to investigate the effect of variable voltages on tissues, temperature distribution and voltage requirement for radiofrequency ablation in human lung tumor by simulation model, in order to find the effect of this technology, in realistic clinical treatment. A three-dimensional right human lung and tumor has been modelled from, 2D medical image data of lung tumor patient for performing temperature-controlled RFA. This study considers the effect of using single Trocar probes in the Radiofrequency Ablation, in the lung tumour RFA and the physics behind Radiofrequency (RF) heating is discussed, to establish hyperthermia treatment planning protocols for deep seated tumours inside complex lung anatomy. The whole process is done on COMSOL MULTYPHYSICS 5.2. The temperature distribution inside the tissue and at various points inside the tumour has been predicted, by integrating two different modules of COMSOL MULTIPHYSICS (the electric currents module and the bio-heat transfer module). The results show that, the effective tumor ablation essentially depends upon, exposure time and on voltage range. The study further evaluates the range of input voltage requirement, for attaining safe ablation of tumor tissue without damaging healthy tissue during temperature controlled RFA of lung tumor. The results from the current study may be useful for the clinical practitioners, by providing them guidelines and it could make the RFA more effective and reliable.
Authors and Affiliations
Gurwinder Singh, Mahakdeep Singh
Keywords
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