Pre-stroke statin use was associated with lower risk of in-hospital death in nonthrombolysed patients
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 4
Abstract
Background: Prior studies suggested that statins might have a neuroprotective effect in patients with acute ischemic stroke. The aim of this study was the evaluation of the short-term effects of statins following ischemic stroke among non-thrombolysed patients. Methods: In this cohort retrospective study we have included 810 ischemic stroke patients (mean age 69.7±11.5, 48.6% females), not-thrombolysed on admission. Based on their prior medication history patients were categorized into pre-stroke statin user and non- statin user patients. The risk of in-hospital mortality was compared between two groups. Results: Of the 810 ischemic stroke patients, 146 (18.2%) were using a statin before stroke. Statin therapy before stroke-onset was associated with a lower risk of in-hospital mortality (3.4% vs. 26.9%), p<0.001. In the multivariable analysis, statin use was independently associated with a favorable outcome (OR = 0.119, 95% CI = 0.047-0.299, p < 0.001). Conclusion: Prior statin therapy in patients with acute ischemic stroke non-thrombolysed patients is associated with lower risk of in-hospital death, and this is independent of other risk factors.
Authors and Affiliations
Nazim Dakaj, Argjend Shala, Fisni Jashari, Dren Boshnjaku, Dardan Jashari, Granit Xhiha, Zylfije Hundozi
Keywords
Related Articles
- EP ID EP40037
- DOI -
- Views 270
- Downloads 0
Clinicopathological Analysis of Benign tumours of the Sinonasal tract
Background: The nasal cavity and the paranasal sinuses form a single functional unit. Sino nasal tumours are characterized by low incidence, nonspecific symptoms, and late presentation. The sinonasal tumours encompass a...
Non Rotation of Gut - A Case Report
Intestinal non-rotation is a congenital anomaly of rotation of the mid gut. During the development of the embryo the gut undergoes umbilical herniation because of the smaller abdominal cavity. When it re-enters the abdo...
Estimation of Erythrocytic Superoxide Dismutase in Multi Infarct Dementias
Introduction: In multi infarct dementias (MID) neuronal damage might result from increased exposure to free radicals coupled with deficit of antioxidants. Antioxidant enzyme, erythrocytic superoxide dismutase (ESOD), ha...
A Cross-Sectional Study on Knowledge, Attitude and Practice on Blood Donation among Medical Students of South India
Background: Safe blood is a critical component in improving the health care and in preventing the spread of infectious diseases globally. Millions of lives are saved each year through blood transfusions, but yet the qua...
The Effect of Rose Water Inhalation on Cardiac Parasympathetic Activity
Objectives: Olfactory stimulus can affect the autonomic balance via communicating neural pools of central nervous system. Rose water affects the autonomic balance and is used in traditional medicine. Methods: This self...