Preclinical evaluation of a novel compound, 4-chlorothiophene for analgesic activity in swiss albino mice
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Background: Pain is one of the most common sensory and emotional experiences which may lead to physiological and psychological stress. Analgesic drugs are commonly used to alleviate pain sensation in several health illnesses. Chronic use of currently available analgesics such as opioids and nonsteroidal antiinflammatory drugs (NSAIDs) may cause several adverse effects in the body.Still there exists a need for search of an ideal analgesic. Aim: To evaluate the analgesic activity of a novel compound, 4-chlorothiophene in Swiss albino mice.Material and methods:The central analgesic activity of 4-chlorothiophene was evaluated by eddy’s hot plate method and early phase of formalin test whereas peripheral activity was evaluated by the late phase of formalin test. Results:40 mg/kg dose of 4-chlorothiophene has shown maximum Pain Inhibition Percentage (PIP) of 35.41% when compared to 128% by morphine in eddy’s hot plate method. Under formalin test, it has shown 19.28% in early phase and 42.55% in late phase compared to 17.72% and 47.37% by aspirin. The results were statistically significant with p<0.05.
Authors and Affiliations
Kummara Muni Kumar, Gondi Surendra kumar
Keywords
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- EP ID EP377171
- DOI 10.9790/0853-1707024247.
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