Preclinical evaluation of hepatoprotective activity of Grewia hirsuta extract on ethylene glycol induced liver damage in Wister albino rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 6
Abstract
The extract of Grewia hirsuta were screened for its Hepatoprotective activity in ethylene glycol induced liver damage in Wister albino rats. The extracts at dose of 250, 750 mg/kg were administered orally once daily. The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transminase (SGPT), serum alkaline phosphatase (ALP) total bilirubin, SOD and catalase were restored towards normalization significantly by the extracts. Cystone was used as standard reference and exhibited significant Hepatoprotective activity against ethylene glycol induced hepatic damage in rats.
Authors and Affiliations
Shaik Rabbani Basha, Revena Siddapa D, Shaik Jilani, Gowtham Kumar K,Veena V
Keywords
Related Articles
- EP ID EP33354
- DOI -
- Views 270
- Downloads 0
In-vitro Antioxidant activities of hydro alcoholic extracts of Trigonella foenum-graecum seeds, Cinnamomum verum bark and Carica papaya leaves and seeds
Background: Oxidative stress and free radical damage have been implicated in the pathogenesis of various diseases like cancer. Apart from the human body’s antioxidant mechanisms several dietary constituents could aid i...
RP-HPLC method development and validation for simultaneous estimation of Amlodipine besylate and Telmisartan in tablet dosage form
RP-HPLC method was developed and validated as per ICH guidelines for the estimation of Amlodipine and Telmisartan. Simultaneous Estimation of Amlodipine and Telmisartan were carried out by RP- HPLC using Phosphate buf...
Formulation and evaluation of biodegradable Ondansetron hydrochloride implant
Implantable drug delivery systems are used to deliver drugs for longer period of time, beneath the skin. These drug delivery systems are implanted subcutaneously and drug is supposed to be released in sustained manner...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF CEFDINIR IN BULK AND CAPSULE DOSAGE FORM
A simple, specific, accurate, rapid, inexpensive isocratic Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative determination of Cefdinir in pharmaceut...
MECHANISM OF DRUG LOADING, EVALUATION AND APPLICATIONS OF ERYTHROCYTES AS CARRIERS FOR DRUG TARGETTING
Resealed Erythrocytes are of appropriate size and shape to carry drugs. They are biocompatible and they have minimum toxic side effects. Minimum leakage can be observed before they reach the target site and they are ab...