Prediction of Insensate Peripheral Neuropathy in Diabetics using “Semmes-Weinstein Monofilament” Examination
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 12
Abstract
Background & Objective Diabetic Peripheral neuropathy (DPN) is a debilitating long term complication of Diabetes Mellitus, but has the advantage of being diagnosed early and its course slowed. The Semmes-Weinstein Monofilament examination is appropriate for early diagnosis of neuropathy, as a simple screening instrument generalizable to the clinical setting. The aim of this project is to study the incidence of peripheral neuropathy among diabetics using the 5.07/10 g Monofilament, and determine the most sensitive site on the foot for its use. Methods A random sample of 120 patients were studied. Monofilament was applied to the plantar surface of 4 sites of both feet. Inability to perceive the sensation at any one site before the monofilament bends within a contact time of 2 seconds, was considered abnormal. The data were analyzed using SPSS 17 Statistical Program. Two-sample t-Test was done to study the prevalence. Results and Interpretation Total of 42.5% subjects were recently (less than or equal to one year) diagnosed as cases of diabetes. Out of these subjects, 27% had already some form of neuropathy present in their feet. It was observed that the duration of morbidity significantly affects the setting in of neuropathy among diabetics (p = 0.005), especially patients with diabetes for over 10 years tend to develop neuropathic symptoms over time. The most commonly affected site was found to be the plantar aspect of the great toe of the left foot (83%), in accordance with the gait cycle. Conclusions The management of DPN needs to be individually based on co morbidities and tolerability to medications. Determination of an appropriate site for testing the Monofilament reduces the possibility of false negatives, and makes this bed side tool more suitable for use for determination of neuropathy.
Authors and Affiliations
Archith Boloor, Snigdha Bhatia, Jagadish Rao Padubidri
Keywords
Related Articles
- EP ID EP183041
- DOI -
- Views 144
- Downloads 0
Identification of Metabolites through GC/LC–MS Processed Data using Different Reference Libraries and Their Comparison
Much significant advancement has been reported in the last few years in the field of metabolomics studies. The high-end computer applications are already contributing to the research and analysis in the field of life sci...
The Ameliorative Effects of CE (A Chicken Extract) on Learning and Memory Function of Restraint-Stressed Mice
In this study, we studied the effects of Chicken Essence (CE) on learning and memory function of restraint-stressed mice. Male Kunming mice of 7-week-old were randomly divided into five groups as follows: normal control,...
Synthesis and Biological Evaluation of Andrographolide Derivatives as Potential Anti-Inflammatory Agents
Background Persistent inflammation might induce lipid metabolism disorders, which affected a significant proportion of the population worldwide, such as serious infections, cardiovascular diseases and autoimmune diseases...
The Protective Effect of Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection on Isoproterenol-Induced Acute Myocardial Infarction in Rats
Salivae miltiorrhizae liguspyragine hydrochloride and glucose injection (SGI) are widely used in the clinical treatment of ischemic cerebrovascular diseases, but researches on the prevention and treatment of acute myocar...
Paediatric Appendicitis: Three-year Experience in a Secondary Care Hospital
Objective To analyze cases of acute appendicitis in the pediatric population and find the effectiveness of ultrasonography and laparoscopic appendectomy in patients attending the referral hospital of Andaman & Nicobar Is...