Prediction of the ligands having the inhibitory activity against the HCV non-structural protein 5B polymerase
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2015, Vol 5, Issue 8
Abstract
Objective: To find similar compounds of rhodanine inhibitors of HCV non-structural protein 5B (NS5B) through exploring the PubChem database. Methods: We used the data mining of these ligands and we studied molecular docking of these ligands with the enzyme HCV NS5B for knowing inhibitory activity. We used the the Knime software for the data mining and the USCF Chimera and Molecular Operating Environment for study the molecular docking. Results: As a result, the discovery was two new inhibitors of NS5B HCV, namely CID 211702 and CID 13752. Conclusions: Two new ligands, CID 211702 and CID 13752, were discovered for the inhibition of the HCV and can be used to invent new medicines against the cancerous diseases.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP228117
- DOI 10.1016/S2222-1808(15)60906-9
- Views 89
- Downloads 0
Evaluation of usefulness of pleural fluid adenosine deaminase in diagnosing tuberculous pleural effusion from empyema
Objective: To evaluate the utility of adenosine deaminase activity in the pleural fluid for the diagnosis of tuberculous pleural effusion from empyema of non-tubercular origin. Method: A retrospective analysis of data wa...
Appendicular perforation in dengue fever: our experience
Dengue viral infections have become one of major emerging infectious diseases in the tropics. Acute abdomen occurring in dengue viral infection is not uncommon. The spectrums of acute surgical emergencies which raise sus...
Nosocomial and community acquired uropathogenic isolates of Proteus mirabilis and antimicrobial susceptibility profiles at a university hospital in Sub-Saharan Africa
Objective: To ascertain antimicrobial susceptibility profile of Proteus mirabilis (P. mirabilis) from clinical urine specimens at a university hospital in the spate of its recorded increasing resistance patterns.Methods:...
An evaluation of National Anti-malaria Programme in a district of Karnataka, India
Objective: To assess the implementation of ongoing National Anti-Malaria Programme, malaria surveillance and the awareness of adult responsible respondents regarding mosquito borne diseases in Raichur District. Methods:...
The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings
Phyllanthus niruri L. (Euphorbiaceae) (P. niruri) has traditionally been used in many tropical countries to treat various ailments, such as kidney stones, chronic liver diseases, diabetes and viral infections. The versat...