Predictive and Prognostic Molecular Factors in High Grade Gliomas
Journal Title: Scholars Journal of Medical Case Reports - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Gliomas are the most common primary brain tumor in adults. In addition to the histological grade, knowledge at the molecular level of these tumors is important in the management of these tumors. 1p/19q-codeletion is an important molecular factor seen in oligodendroglial grade tumors and also confers a favorable prognosis as well as predicts good response to chemotherapy and radiotherapy. IDH mutation also helps in better prognosticating patients with grade III gliomas. Patients of glioblastoma with methylated MGMT promoter, confers a survival advantage when treated with temozolomide and thus acts as a predictive marker. These various molecular factors help's not only in prognosticating glioma patients but also aids in tailoring treatment.
Authors and Affiliations
Minu Reeba Thomas
Keywords
Related Articles
- EP ID EP482470
- DOI -
- Views 63
- Downloads 0
Secondary vesical calculus resulting from the migration of an intra uterine device – a rare case report
Migration of the intrauterine devices (IUD) into the bladder is a rare complication but it can cause further grievous consequences. Here we present a case of secondary vesical calculus resulting from migrated IUD. The ca...
Splenic injury with right rib fractures- Case report
A 62-year-old male wearing a seatbelt drove and stopped his car around a curve. Another car, driving at a right angle to the curve at a speed of 20-30 km, directly collided into the right side (driver’s side) of the car...
Hoffman's syndrome as initial manifestation of hypothyroidism a rare presentation: a Case report
Hoffman's syndrome is characterized by muscle stiffness and muscle pseudo hypertrophy in adult rarely a early manifestation of hypothyroidism. Here we present a 18 year-old adolescent diagnosed as Hoffman's Syndro...
A fatal case of septicemia caused by multi-drug resistant (MDR) Serratia marcescens; a case report from a tertiary care hospital
There has been an increase in hospital acquired infections due to organisms like Pseudomonas spp., Acinetobacter spp and other members of enterobacteriaceae. Serratia spp. is now emerging as an important nosocomial patho...
Injection Site Infection Following Intralesional Corticosteroid Use in Refractory Plantar Fasciosis
Chronic heel pain following plantar fasciosis is a nagging problem that is often managed conservatively with satisfactory results. Refractory cases may require local corticosteroid injections as part of treatment. The st...