Predictive factors of esophageal stricture after definitive chemoradiation therapy for esophageal carcinoma: A retrospective single institute study
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 9, Issue 3
Abstract
Background: Esophageal cancer is the eighth most common cause of cancer. Chemoradiation is the well established approach for treatment of esophageal carcinoma. Radiation-induced esophageal stricture is one of the most common late complications of RT usually occurs 3–8 months after completion of RT. Esophageal stricture is often observed after radiation therapy despite good tumor response and hence the quality of life (QOL) suffered. The purpose of this to identify patient, tumor, and treatment factors that have a significant impact on the likelihood of developing esophageal stricture following definitive chemoradiation therapy (CRT) for esophageal/ gastroesophageal junction (GEJ) carcinoma. Methods: Retro one year audit of 40 patients with biopsy proven esophageal cancer who underwent definitive concurrent chemoradiationin Department of radiation oncology at Guru Gobind singh medical college and hospital. Barium swallow was performed for all patients within 3 months after completion of the radiation therapy and the esophageal stricture was evaluated. We then tried to establish the correlation between the stricture levels after radiation therapy. Time to stricture was defined as elapsed time from completion of RT to first dilatation. Prophylactic dilatations were not performed. Multiple patient, treatment, and tumor characteristics were evaluated in terms of risk for stenosis and was statistically evaluated. Results: Tumor location was significantly associated with stricture risk, with more superior tumors having higher rates of stricture. Patient age, sex, current or previous smoking history, alcohol use, stage group, RT technique, and the use of a dose above 54 Gy were not associated with stricture risk.Conclusions: Female sex, extent of circumference involved, site of the disease, severe esophagitis during radiotherapy are important factors predicting occurrence of post radiotherapy stricture in carcinoma esophagus.
Authors and Affiliations
Deepak Kumar Uppal, Manraj Singh Kang, Taranjeet Kaur, Pardeep Garg, Raja Paramjeet Singh Banipal, Sapna Marcus Bhatty, Romi Kant Grover, Gaurav Jaswal
Keywords
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- EP ID EP516847
- DOI 10.26611/1021935
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