Predictive value of serum Cystatin C in post-operative renal dysfunction following coronary artery bypass grafting
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 3
Abstract
Context: Acute kidney injury (AKI) is a potential complication following coronary artery bypass grafting (CABG). Thecurrent pilot study evaluates the predictive value of serum Cystatin C (Cys C) for post-operative renal disease (PORD) after CABG. Methods: Patients admitted for coronary artery bypass grafting in Sir J J Hospital, Mumbai, were prospectively studied and their serum creatinine, Cys C, troponin I and potassium levels were measured pre and post operatively. Unpaired t test used to compare 2 groups. ROC curve analysis was done to measure the cut-off value of serum Cys C to predict PORD in patients after CABG. Results: Serum Cys C showed a significant rise in subjects who developed PORD post CABG compared to the non- PORD group (p < 0.0001). Mean GFR based upon serum creatinine and Cys C was significantly lower in PORD group as compared to the non-PORD group but the difference was more significant when Cys C based GFR was used (p < 0.0001) in comparison to the GFR based upon serum creatinine (p < 0.05). Conclusion: Measurement of serum Cys C along with cardiac Troponin I and other routine biochemical tests can be useful to improve the strategies for myocardial protection, to assess degree of damage to myocardium following CABG procedure and predicting surgical and adverse outcomes in the form of PORD.
Authors and Affiliations
Nilanjana Guha Niyogi, S P Dandekar, Shalini Maksane, V W Patil, L G Abhichandani
Keywords
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