Predictors of response to chronic hepatitis C treatment
Journal Title: Annals of Hepatology - Year 2010, Vol 9, Issue 0
Abstract
Nowadays the standard of care for hepatitis C therapy is based on Pegylated interferon alpha and ribavirin (Peg IFN/RBV). This combination has led to a sustained virological response rate (SVR) of 50 to 80% depending on genotype. This is still low, considering the side effects, overall costs and duration of therapy. So far, strategies to foresee SVR have been described such as genotype, fibrosis stage, viral load and gammaglutamyltransferase.In addition, new data has recently been provided on predictive factors of SVR like genetic polymorphism related to race, insulin resistance and viral kinetics. This review aims to discuss these predictive factors of therapy that might help the decision about starting or discontinuing therapy in chronic HCV infected patients.
Authors and Affiliations
Henrique Moraes Coelho, Cristiane Villela-Nogueira
Keywords
Related Articles
- EP ID EP77964
- DOI -
- Views 118
- Downloads 0
Focal nodular hyperplasia and hepatic regenerating nodules in pediatric oncology patients: how much invasive approach is necessary?
[b]Introduction[/b]. Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported...
Mexican-native human echinococcosis: Case report of an underestimated disease
Mexico is considered a virtually free region of cystic echinococcosis. Almost all case reports within the country involve immigrants or traveling patients. This manuscript presents a Mexican-native human echinococcosis t...
Pigmented hepatocellular adenoma with β-catenin activation: case report and literature review
Hepatocellular adenomas (HCAs) are benign liver tumors recently characterized into 4 different types according to genetic, pathological and clinical features. The prognosis is not well established yet and malignant tran...
A comparison study of local injection and radiofrequency ablation therapy for traumatic portal vein injure guided by contrast-enhanced ultrasonography
Background. To compare local injection of hemostatic agents and radiofrequency (RF)-assisted hemostasis in the management of bleeding from the portal vein with varying diameters and blood flow velocities. Material and me...
Vitamin D deficiency and vitamin D therapy in chronic hepatitis C
[b]Background[/b]. Vitamin D has immunomodulatory properties, exerts an anti-hepatitis C virus (HCV) effect in vitro and improves response to interferon-based therapy in patients with chronic hepatitis C (CHC). Low serum...