Pregabalin Intoxication in a Patient with Heroin Addiction
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Pregabalin is an anticonvulsant which is an analog of gamma-aminobutiric. It increases normal GABA levels by binding to α2-δ subunit in voltage sensitive calcium channels and inhibiting excitator neuro-transmitter release. It exerts analgesic and anxiolytic effect by decreasing the release of neurotransmitters such as glutamat, noradrenalin and substance P. It is used for treatment of neuropathic pain, fibromyalgia, generalized anxiety disorder, epilepsy, and benzodiazepine and alcohol dependence. The most marked affect stated by users of Pregabalin is euphoria. It is known that, it has a potential of misuse, due to this effect and leads to dependence. The addicts use high doses Pregabalin for getting euphoria effect. The majority of Pregabalin addicts are known to misuse at least one other psychoactive substance or drug previously.We presented a patient with heroin addiction who started to use high dose Pregabalin for recreational purposes. We wanted to draw attention to that pregabalin misuse by itself and in combination should be borne in mind in case of intoxication and effects such as prolonged sinusal bradycardia
Authors and Affiliations
Emine Aslanlar, Zeynep Cura, Mehmet Sari, Ahmet Sonmez, Ozkan Onal
Keywords
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