Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement

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Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement

Journal Title: International Journal of Current Research and Review - Year 2018, Vol 10, Issue 9

Abstract

Objectives: To evaluate and compare Renal, Hepatic and Coagulation profiles in normotensive pregnant females at 20 weeks or more gestation and in cases of Pregnancy induced Hypertension at same gestation. Methods: The study was conducted on 100 pregnant females divided into two groups of 50 each: cases of PIH (Study group) and normotensive pregnant females (Control group) and all these females were at 20 weeks or more gestation. Blood sample was collected at the period of gestation when they attended Gynaecology OPD at Rajindra Hospital, Patiala. Blood Urea, S. Creatinine, S. Uric Acid, S. Transaminases and Platelet count were evaluated and compared. Results: The mean Blood Urea was 25.92±6.16 mg% (study group) compared to 24.60±3.21 mg% (control group) (p=0.1823).The difference did not attain statistical significance. The mean S. creatinine was 1.05±0.19 mg% (study group) compared to 0.71±0.20 mg% (control group) (p<0.0001) while the mean S. uric acid was 5.43±1.25 mg% (study group) compared to 3.86±0.72 mg% (control group) (p<0.0001) and the difference was statistically highly significant. The mean AST levels were 57.42±58.26 IU/L(study group) compared to 25.02±6.32 IU/L(control group) (p=0.0002) while the mean ALT levels were 51.80±53.98 IU/L(study group) compared to 24.04±8.56 IU/L(control group)(p=0.0005). The mean platelet count was 223700.00 ± 70239.02 mm3 (study group) compared to 314860.00±33815.83 mm3 (control group) (p<0.0001). The difference was statistically highly significant. Conclusion: Patients with PIH have altered renal, hepatic and coagulation profiles thereby deranging the function of different organs. Timely assessment of various blood parameters in such patients will help in preventing occurrence of PIH and in planning proper intervention to improve both maternal and fetal outcome in established pre-eclamptic women.

Authors and Affiliations

Dr. Karanpreet Bhutan

Keywords

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EP ID EP542956
DOI 10.31782/IJCRR.2018.10907
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