Pregnancy outcome of recurrent spontaneous abortion in Wilson’s disease after decoppering therapy
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 4
Abstract
Purpose of Investigation: To report pregnancy outcome after decoppering therapy in patients with recurrent spontaneous abortion (RSA) and Wilson’s disease (WD). Materials and Methods: In a retrospective study, 12 WD patients who suffered from RSA were treated with dimercaptosuccinic acid and zinc gluconate. The average daily dose of dimercaptosuccinic acid and zinc gluconate was 1.00 and 1.68 grams, respectively. Dimercaptosuccinic acid was discontinued, while zinc gluconate was continued during pregnancy. The primary clinical outcomes were the pregnancy outcome after decoppering therapy and the mean age at diagnosis. Results: Six patients conceived at least once after treatment. Five of them had successful pregnancies with seven healthy live births. Mean age at diagnosis was significantly lower in patients who delivered healthy babies than in those who failed to conceive. Conclusions: Decoppering therapy is efficacious in reversing the pregnancy outcome of RSA in patients with WD, especially in the women who are diagnosed at young age. Age at diagnosis is an important risk factor that affects the pregnancy outcome in these patients.
Authors and Affiliations
L. Wu, M. Zheng, X. Tong, Y. Liu, H. Han
Keywords
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- EP ID EP673417
- DOI 10.12891/ceog4781.2019
- Views 53
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