Pregnancy Outcomes in Women with Homozygous Beta Thalassaemia A single-centre experience from Oman
Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 3
Abstract
Objectives: Pregnancy in women with homozygous beta thalassaemia (HBT) carries a high risk to both the mother and fetus. Te aim of this study was to investigate pregnancy outcomes among this group at a single tertiary centre. Methods: Tis retrospective descriptive study was conducted between January 2006 and December 2012 on all women with HBT who received prenatal care and subsequently delivered at Sultan Qaboos University Hospital, Muscat, Oman. Women who delivered elsewhere and women with the beta thalassaemia trait were excluded. Results: Ten women with HBT were studied with a total of 15 pregnancies and 14 live births. Te mean maternal age ± standard deviation (SD) was 27.9 ± 3.7 years, with a range of 24‒35 years. Tere were 14 spontaneous pregnancies and one pregnancy following hormone treatment. Eight women had been on chelation therapy before pregnancy, one of whom needed chelation during late pregnancy. Of the pregnancies, 93% had a successful outcome with a mean ± SD gestational age at delivery of 38.6 ± 0.9 weeks, with a range of 37‒40 weeks. Eight babies (57%) were delivered by Caesarean section. Te mean ± SD birth weight was 2.6 ± 0.2 kg, with a range of 1.9‒3.0 kg. Tree babies (21%) were born with low birth weights. Conclusion: Pregnancy is safe and usually has a favourable outcome in patients with HBT, provided that a multidisciplinary team is available. Tis is the frst study of Omani patients with HBT whose pregnancies have resulted in a successful outcome.
Authors and Affiliations
Nihal Al-Riyami| Department of Obstetrics & Gynaecology, Sultan Qaboos University Hospital, Maha Al-Khaduri| Department of Obstetrics & Gynaecology, Sultan Qaboos University Hospital, Shahina Daar| Department of Haematology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
Keywords
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