Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat

Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 4

Abstract

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted in a significant increase in the levels of calcium and oxalate. Treatment of ethanolic extract of Aristolochia indica 100mg/kg body weight for 30 days revealed a dose –related effect in the reduction of lithogenic substances, following glycolic acid induced urolithiasis. Simultaneous oral treatment with at a dose of ethanolic extract of Aristolochia indica 100mg/kg for 30 days significantly reversed the ethylene glycol induced nepharolithiasis and urolithiasis. Presumably by preventing the urinary supersaturation of lithogenic substances. Especially of oxalate and calcium. These observation indicate that ethanolic extract of Aristolochia indica can play an important role in the prevention of disorders associated with kidney stone formation.

Authors and Affiliations

Kumbhar B. P| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India, Burli S. C| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India, Mali S.S., Dongare S. D| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India, Patrekar P. V| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India

Keywords

Related Articles

Study of Cardiac markers in Acute Myocardial Infarction Patients

Introduction: Acute Myocardial infarction (AMI) or Myocardial infarction (MI) (ie, heart attack) is the irreversible death (necrosis) of heart muscle due to prolonged lack of oxygen supply (ischemia). Biochemically the...

Effect of Melia azedarach and Dodonaea viscosa aqueous leaf extracts on fertility in male albino rats

Medicinal plants play a key role in human life as they are helpful in curing several diseases. They not only support health by the pharmacological nature but also utilizable as contraceptive options. The present study...

Gold Nanoparticles synthesis, properties, and forthcoming applications – A review

Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characte...

Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the d...

Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be...

Download PDF file
  • EP ID EP14280
  • DOI -
  • Views 328
  • Downloads 14

How To Cite

Kumbhar B. P, Burli S. C, Dongare S. D, Patrekar P. V (2014). Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat. Indian Journal of Pharmaceutical and Biological Research, 2(4), 114-120. https://europub.co.uk./articles/-A-14280