Preliminary phytochemical screening and in vitro antioxidant activity of Sida Acuta Burm
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 2
Abstract
Sida acuta is shrub indigenous to pantropical areas, widely distributed in regions and found in pastures, waste lands, cultivated lands, roadsides, lawns and planted forests. Sida acuta is ethanomedically used as treatment of diuretic, asthma, fever, headache, cough, cold, ulcer, anthelmintic, snake bite, urinary disease, female disorders, sedative, eczema, kidney stone, elephantiasis, testicular swelling, poultice for dandruff, rheumatic affections, facial paralysis, pulmonary tuberculosis, gonorrheae. The phytochemical screening revealed the presence of tannin, saponin, flavonoid, terpenoids, cardio glycoside, vitamin composition was thiamine, niacin, ascorbic acid, tocopherol, riboflavin and mineral composition was calcium, magnesium, zinc, steroids, phenolic compounds, sesquiterpene, alkaloid cryptolepine, quindoline, quindolinone and fixed oil. The hydro alcohol extract was subjected to preliminary phytochemical analysis and the same was evaluated for its antioxidant studies by in vitro methods such as hydrogen peroxide scavenging activity, reducing power assay and total antioxidant capacity. The phytochemical analysis indicated the presence of alkaloids, carbohydrates, cardio glycoside, sterols, saponins, flavonoids,protein and aminoacids, terpenoids, resins, gum mucilage, quinone and coumarin. The antioxidant studies concentration (IC50) of Sida acuta of hydrogen peroxide scavenging effect was found to be 1.83μg/mL in comparison with ascorbic acid (0.95μg/mL). Inhibitory concentration (IC50) of Sida acuta for reducing power effect is found to be 142μ/mL in comparison with ascorbic acid 15μg/mL and Inhibitory concentration (IC50) of Sida acuta for total antioxidant capacity was found to be 185μg/mL in comparison with ascorbic acid 159μg/mL. The present research draws the conclusion that this Sida acuta plant showed mild antioxidant effect, which may be due to the phytoconstituents.
Authors and Affiliations
Krishnaveni A
Keywords
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