PREPARATION AND CHARACTERIZATION OF SOLID SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM BY ADSORBENT TECHNIQUE TO IMPROVE DISSOLUTION PROFILE OF POORLY AQUEOUS SOLUBLE DRUG RAMIPRIL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
The main purpose of this work is to prepare solid self-microemulsifying drug delivery system (S-SMEDDS) to improve drug dissolution profile of poorly aqueous soluble drug. Optimized formulation of SMEDDS consists of Ramipril (RAM) (10 mg), Tween 80 (160mg), Cremophor EL (640mg) and Capmul MCM (CAP) as oil (200mg). SMEDDS was adsorbed at various SMEDDS: adsorbent ratio i.e. 3:1, 1:1, 1:3 on the solid carrier Aerosil 200. Powder flow properties and drug content were evaluated of the resulting formulations. The S-SMEDDS which showed maximum drug content in formulation & good flow properties were further evaluated & characterized for globule size, reconstitution properties, DSC, SEM & in-vitro dissolution profile. Converting liquid SMEDDS formulation to solid SMEDDS formulation is easy by adsorption on solid carrier technique. Formulation to Aerosil 200 ratio of 1:1 showed passable flow properties and high drug content. Also the reconstitution properties of the S-SMEDDS were not much altered. DSC study revealed that the drug was in solubilised form. SEM photographs showed that the formed particle were smooth and not much aggregation. Dissolution profile for Ramipril from S-SMEDDS was significantly higher than the conventional capsule. After three month stability study S-SMEDDS did not show any drug precipitation as well as phase separation. Our studies suggest that solid SMEDDS could be used as an effective oral solid dosage form to improve the dissolution profile of poorly aqueous soluble drug.
Authors and Affiliations
Mithun Bandivadekar , Shyam Pancholi , Nagsen Shelke
Keywords
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