Preparation and Characterization of sPLGA Complex Microspheres as a Promising Carrier for Cucurbitacin B
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 6
Abstract
The purpose of this research was to develop a new kind of GA-CS/sPLGA complexed Microspheres delivery system for CuB. In this work, star-shaped poly(lactic-co-glycolic acid) (sPLGA-COOH) and chitosan modified with glycyrrhetic acid (GA-CS) were successfully synthesized. The GA-CS/sPLGA complexed Microspheres for CuB was prepared by emulsion evaporation method. Futhermore, CuB-loaded Microspheres formulations were optimized. The release behaviour of CuB-loaded Microspheres in vitro were also examined. It was showed that CuB-loaded amount of Microspheres could reach 58.78%±1.288 by adding GA-CS into the external water phase. The size of corresponding CuB-loaded Microspheres was 370±16.14 nm in diameter, and zeta potential was negative 10.86±0.4790 mV measured by laser light particle size/zeta potential analysis. The results indicated that the complexed GA-CS/sPLGA Microspheres raised the entrapment efficiency for CuB. In vitro drug release demonstrated that complexed GA-CS/sPLGA Microspheres had many advantages such as sustained release and low initial drug burst.
Authors and Affiliations
Yi Zhang, Yue Liu, Hewei Shao, Xiaoyan Han
Keywords
Related Articles
- EP ID EP342379
- DOI 10.9734/BJPR/2016/22575
- Views 91
- Downloads 0
Rumex usambarensis (Dammer) Leaf and Stem Extract Effect on Body Weight and Lipid Profile: A Study in Albino Rats
Aims: The aim of the study was to determine the effect of Rumex usambarensis plant extract on body weight and lipid profile of fattened albino rats. Study Design: This was an in-vivo experimental study in laboratory ani...
Evaluating the Rationality of Antibiotic Dispensing in Treating Common Cold Infections among Pharmacists in Baghdad – Iraq
Background: Common cold is a self limited viral infection, which can be treated symptomatically without the need to antibiotics which are not effective or curative. This study aimed to evaluate the practices of community...
Review of Traditionally Used Medicinal Plants by the Kipsigis Community in Kenya
Background: Every community in Kenya have their own ways of providing good health care services for its members. Such services are geared towards providing therapeutic and medical related services for the upkeep of good...
Lubricating Properties of Co-processed Coconut Oil in Paracetamol Tablets Formulation
Objective: Lubricants are additives which reduce friction and so essential components of drug formulation. This piece of work was initiated to evaluate coconut oil as a co-processed lubricant in the formulation and compr...
A New Approach for the Treatment of Diabetes and Nicotine Induced Cataract by Modulating Specific Ion-Channels Function in Rat Lens
Aim: Cataract is an eye disease characterized by a cloudiness of the normally transparent crystalline lens. Diabetes and smoking are the known risk factors for cataract development. It is well known fact that inorganic i...