PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF KETOROLAC TROMETHAMINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
The objective of the present study is to prepare sustained-release ketorolac tromethamine microspheres of bovine serum albumin in different ratios by the emulsion cross-linking method using epichlorohydrin. The prepared microspheres were subjected to various physicochemical evaluation and in vitro release studies. The drug release from microspheres of 1:5 ratios is the most constant and prolonged drug release is diffusion followed by erosion. The characteristics of the prepared microspheres are conducive to the formulation of the sustained release drug delivery system.
Authors and Affiliations
Manoj Mishra , Vipan Kamboj , Prabhakar Verma , Vijay Nigam
Keywords
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