Preparation and evaluation of Maltodextrin based Proniosomes containing Capecitabine
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 7
Abstract
Maltodextrin based capecitabine proniosomes were fabricated by conventional slurry method with different surfactant: cholesterol molar ratio keeping constant capecitabine and dicetyl phosphate concentration. The fabricated proniosomes were evaluated for FTIR and flow properties. Further proniosomes were hydrated to get desired niosomes and the obtained niosomes were subjected for various evaluation parameters such as entrapment efficiency, in vitro drug release and stability studies as per ICH guidelines. The entrapment efficiency followed the trend, span 80 (C18)> span 20 (C12) as increasing the alkyl chain lengths are leading to higher entrapment efficiency. The in vitro data suggest biphasic drug release, initial burst followed steady state. In all the case, best-fit model was found to be matrix with Peppas exponential value was greater than 0.5 indicating drug released by non Fickian (anomalous) mechanism. The result of investigation demonstrated that proniosomes offers an alternate drug carrier with targeted specificity.
Authors and Affiliations
Srikanth| Department of Pharmaceutics, V.L.College of Pharmacy, Raichur, India, Y. Anand Kumar| Department of Pharmaceutics, V.L.College of Pharmacy, Raichur, India, C. MallikarjunaSetty| Oxford College of Pharmacy, Bengaluru, India, India
Keywords
Related Articles
- EP ID EP16053
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(7).2856-2
- Views 337
- Downloads 18
Speciation, biofilm formation and antifungal susceptibility of Candida isolates
Recently, an increase in the incidence of infections caused by fungi especially non-albicans Candida species has been reported. Several virulence factors like biofilm formation, toxin production and presence of adhesin...
Pharmacological investigation of leaves of Polypodium decumanum for anti-bacterial activity against gram-positive and gram-negative bacteria
The widespread use of antibiotics has led to an increase in multidrugresistant bacteria, which represent a serious risk of infection, in view of this problem the aim of this research was performed to characterize the an...
Formulation and evaluation of taste masked Amlodipine Besylate Fast-dissolving Sublingual Tablets
Aim: In the present study was to taste mask the Amlodipine Besylate (AML) by forming complex with Eudragit EPO by and further to enhance the dissolution rate AML by formulating these drug polymer complex (DPC) into fas...
CHARACTERIZATION OF HIGH ACTIVITY DRUG-STIMULATED ATPase OF MULTIDRUG RESISTANT LEISHMANIA DONOVANI AMASTIGOTE CELLS
Background: The emergence of drug resistance and the limited knowledge of the mechanisms by which the parasites acquire resistance are the major obstracle for the control of leishmaniasis. Methods: The present investig...
A validated analytical method for the estimation of Oxetacaine from its pharmaceutical formulation by RP-HPLC
OBJECTIVE: The aim of the current study was to develop an analytical procedure for the determination and quantification of Oxetacaine, from its marketed formulation which is simple, precise, accurate and a validated, r...