PREPARATION AND EVALUATION OF TASTE MASKED QUICK DISSOLVING FILM OF LORNOXICAM
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 1
Abstract
Rheumatoid arthritis is the chronic painful disease of joint destruction and functional disability needing immediate action with patient compliance. Pain relieving Quick dissolving film (QDF) will be an accurate patient acceptable solution for this condition. Lornoxicam (LXM) is a non-steroidal anti-inflammatory drug (NSAID) with half life 3-5 hours, complete absorption from GIT (90-100%) having advantage from a tolerability standpoint. LXM has bitter taste thus to improve the palatability, the drug was complexed with Beta Cyclodextrin in different ratios using kneading method by optimizing the kneading time. Taste evaluation was done by human volunteer and UV method. The optimized drug-beta cyclodextrin complex was incorporated in QDF by solvent casting technique using PVA: Pullulan as polymers and PEG 400 as plasticizer. The optimization of concentration of PVA: Pullulan and PEG 400 was done by 32 factorial design to observe its effect on disintegration time, drug release in 20 minutes, tensile strength and folding endurance as dependent variable. The optimized batch QDF1 gave disintegration in 22 second and 98 % drug release in 20 minutes with suitable strength and flexibility. It can be concluded that the development of Quick dissolving film of Lornoxicam could give quick relief from the pain of rheumatoid arthritis with greater compliance compared to other conventional dosage forms.
Authors and Affiliations
Kinjal R. Shah, Tejal A. Mehta
Keywords
Related Articles
- EP ID EP625109
- DOI -
- Views 88
- Downloads 0
ISOLATION OF ENDOPHYTIC BACTERIA, BIOACTIVE COMPOUNDS AND ITS ANTIVIRAL ACTIVITY AGAINST HERPES SIMPLEX VIRUS TYPE -1
Microbial community has been a major part in the drug industry. They are known for their effectiveness and do not cause any undesirable effects. Exploitation of bacteria could be fruitful for mankind. Bacteria play a maj...
OPTIMIZATION AND VALIDATION OF MODULATED RELEASE FORMULATION OF RANITIDINE HCL BY RESPONSE SURFACE METHODOLOGY
The objective of the present study was, 1) to systematically device a model of factors that would yield an optimized sustained release dosage form of model drug (Ranitidine HCl), 2) to validate the models using R2 v...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF EMBELIN IN EMBELIA TSJERIAM COTTAM
Embelin, a naturally occurring benzoquinone, is obtained from fruits of Embelia tsjeriam cottam, which plays a vital role in the Ayurvedic system of medicine. An approach for the stress degradation was successfully appli...
COMPARATIVE EVALUATION OF POLYHERBAL COMBINATION FOR HYPOLIPIDEMIC ACTIVITY
Hyperlipidemia is defined as increase in the lipid content (group of fat or fat like substances along with their lipoprotein counterpart) in blood. The present study was undertaken to explore the antihyperlipidemic effec...
BIOCHEMICAL, NEUROCHEMICAL AND BEHAVIOURAL RESPONSES FOLLOWING ADMINISTRATION OF 6-FLUORO-3-(PIPERIDIN-4-YL) BENZO[D] ISOXAZOLE DERIVATIVES AND ANTIPSYCHOTIC DRUGS IN MICE
The atypical antipsychotic drugs used in recent times for the treatment of chronic or acute psychotic (CNS) disorders, are found to cause Extrapyramidal side effects (EPS). Earlier studies have revealed that an enhanced...