PREPARATION AND IN VITRO EVALUATION OF SOLID DISPERSIONS CONTAINING NIFEDIPINE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 4
Abstract
The objective of this study was to develop solid dispersions of Nifedipine which has low aqueous solubility and bioavailability. Preliminary solubility studies were carried out using various hydrophilic polymers. The formulations were then optimized and evaluated by in-vitro dissolution studies, X-ray diffraction, FTIR and SEM. Formulation with 1:4:2 ratios of Nifedipine, Labrosol and SLS was found to be the best as it possessed better drug release properties compared to pure drug and other physical mixtures. The optimized formulation SD12 was found to have better drug release of 98.74 ± 5.19% in 90 minutes. From FTIR studies no interaction was takes place between drug and polymers. XRD peaks indicate the successful transformation of drug from crystalline to amorphous form. The final results indicate that the solid dispersion of Nifedipine remained stable over 90 days.
Authors and Affiliations
G. Muralichand, D. V. R. N. Bhikshapathi
Keywords
Related Articles
- EP ID EP618421
- DOI 10.25004/IJPSDR.2018.100408
- Views 72
- Downloads 0
DESIGN AND EVALUATION OF COLON TARGETED DOSAGE FORM CONTAINING MESALAZINE USING PH DEPENDENT POLYMERS
Colonic drug delivery has gained importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis and irritable bowel syndrome but a...
FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF GLIBENCLAMIDE
Matrix type transdermal patches containing Glibenclamide were prepared using three different polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was...
FORMULATION AND EVALUATION OF A MOISTURIZING CREAM USING ALMOND BUTTER
Almond butter is one of the moisturizing agents, which has good emollient and moisturizing properties and hence can be well utilized to design a moisturizing cream, which can provide a good moisturizing property and help...
FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESIVE MATRIX TABLETS: ASSESSMENT OF MYRRH OLEO GUM RESIN AS A NATURAL PHARMACEUTICAL EXCIPIENT
Mucoadhesive polymer owing to its binding capacity with gastric mucin prolongs the gastric residence time and thereby increased drug bioavailability. In the present study, oral controlled release mucoadhesive matrix tabl...
PHYTOCHEMICAL SCREENING AND TLC PROFILE OF FRUITS AND FLOWERS OF ALSTONIA VENENATA R. BR.
Alstonia venenata R. Br. belonging to the family Apocynaceae is a tall evergreen shrub distributed throughout Peninsular India. Stem-bark, root-bark, fruits and leaves are used by many tribal communities and also in Ayur...