Preparation and molecular modeling of radioiodopropranolol as a novel potential radiopharmaceutical for lung perfusion scan
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: Development of easy method for radioiodination of propranolol with high percent labeling yield for the purpose of lung perfusion imaging.Methods: Radioidination of propranolol was achieved using 125I via electrophilic substitution under the oxidative conditions of cholramine-T (CAT). All factors affecting the labeling procedure and labeling yield were studied. Paper electrophoresis and HPLC were performed to determine the radiochemical yield and purity of the 125I-propranolol. Molecular modeling and docking studies were performed to ensure the binding of the newly obtained 125I-propranolol to beta-2 (β2) adrenergic receptor.Results: Radioiodination of propranolol has been successfully achieved with high labeling yield (93.7 ± 0.81% ) . 125I-propranolol was stable for 24 h when kept in dark at ambient temperature. Biodistribution studies showed lung uptake of 21.60 ± 0.03% injected dose/g  (%ID/g) at 30 min post-injection. Molecular modeling confirmed that radioiodination did not affect the binding of propranolol to β2- receptor.Conclusion: Iodopropranolol can be considered as good potential lung perfusion agent as suggested by the results of biodistribution and molecular modeling studies.
Authors and Affiliations
Mohammed A. El-motaleb, Amal S. Farrag, Ismail T. Ibrahim, Mona O. Sarhan, Magda F. Ismail
Keywords
Related Articles
- EP ID EP578263
- DOI -
- Views 60
- Downloads 0
POSTPARTUM HEALTH RELATED QUALITY OF LIFE AFTER DIFFERENT MODES OF DELIVERY AMONG WOMEN IN PAKISTAN: THE NEGLECTED LINK FOR BETTER MATERNAL and CHILD HEALTH
Objective: The present study was designed to evaluate women postpartum quality of life after different modes of delivery in Pakistan.Methods: A descriptive cross-sectional study design was used. A pre-validated tool SF-3...
ASSESSMENT OF AIR POLLUTION TOLERANCE INDEX OF PLANTS: A COMPARATIVE STUDY
Objective: Air pollution is one of the major global tribulations in many developing cities around the world. Addressing this sort of pollution is more intricate than other ecological challenges. As pollution is an upcomi...
ANTIOXIDANT ACTIVITY OF FOURTEEN EULOPHIA SPECIES TRADITIONALLY KNOWN AS AMARKAND
Objective: Amarkand is a group of medicinal plants, of which tubers are regularly consumed by the tribal people in India as food and medicine. It has a strong background of regional ethnopharmacological and food uses. Th...
STUDY ON IN-VITRO ANTIBACTERIAL ACTIVITY OF MUSHROOM COLLECTED FROM JABALPUR REGION
Objective: The aim of the present investigation is to examine the collected wild mushroom for their in-vitro antibacterial activity and cultivation of potential mushroom strains.Methods: screening of mushrooms for in-vit...
SCREENING AND GROWTH KINETIC STUDIES OF WILD CHLOROPHYCEAN FRESH WATER MICROALGAL SPECIES FOR BIOMASS AND BIOFUEL APPLICATIONS
Objective: Microalgae are studied for decades for various products such as, protein rich animal/fish feed, lipids, pigments, neutra ceuticals, therapeutic agents, primary products and biomass. Lipid content was prime tar...