PREPARATION AND PHARMACODYNAMICS STUDY OF INSULIN IMPLANT TABLETS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 4
Abstract
In this study, insulin implant tablets was prepared and its pharmacodynamics was studied in rats. Polylactic acid (PLA) and poloxamers were used as carriers to prepare insulin implanted tablets. In vivo pharmacodynamics of insulin-implanted tablets in rats was investigated. Glucose oxidase method was used to measure blood glucose concentration. The in vitro release of implants was influenced by the amount of Polylactic acid and poloxamer, the cumulative release of insulin was 81.9 ± 1.3% ~ 90.4 ± 1.5% after 36 hours. In vivo pharmacodynamics results showed that insulin implant tablets had a sustained release effect up to 84 h. The quality of insulin implants is easy to control, and the tablets can produce a sustained release effect. It can provide a convenient and effective way for diabetic patients.
Authors and Affiliations
Liandong Hu
Keywords
Related Articles
- EP ID EP622500
- DOI -
- Views 128
- Downloads 0
GC-MS ANALYSIS OF BIOACTIVE PHYTOCHEMICALS PRESENT IN METHANOL EXTRACT OF PLEUROTUS OSTREATUS (JACK EX. FR.) P. KUMM: EVIDENCE FOR ITS MEDICINAL DIVERSITY
The research study was aimed to determine the chemical constituents present in the fungus Pleurotus ostreatus (Jack ex. Fr.) P. Kumm. methanol extract using Shimadzu P 2010 Ultra Gas Chromatography-Mass Spectrometry. GC-...
PHARMACOGNOSTIC STUDY ON “UMIKKADDI GIDA”- A FOLKLORE CLAIM
Pharmacognosy is a branch of pharmaceutical science, which deals with naturally occurring biological products especially those derived from plants. The term Pharmacognosy is derived from two Greek words 'Pharmacon' means...
MARINE ALGAE AS A SOURCE OF PREVENTION AND RELIEF IN THOSE WITH DEPRESSION AND DEMENTIA
Although not as common as those in young adults, the prevalence of late-onset depression has been reported to be increasing in its global incidence. Late-onset depression is generally a product of cognitive deficit and d...
SUCCESSFUL COGNITIVE AGING-PREREQUISITE OF AN IMPROVED QUALITY OF LIFE IN ELDERLY PATIENTS
Addressing the demographic challenges is among the basic political and social priorities of the European Union. The multidimensional problems of advanced and late age (biological, psychological, socio-economic, cultural,...
IN-VITRO CYTOTOXICITY OF MILONINE ISOLATED FROM CISSAMPELOS SYMPODIALIS EICHL (MENISPERMACEAE) ON VERO CELL LINE
The family Menispermaceae is well known for producing various types of alkaloids, especially morphinandienones. Milonine is a morphinandienone alkaloid from Cissampelos sympodialis Eichl, a plant popularly used in northe...