PREPARATION OF INSULIN-PLGA IMPLANT AND ITS EFFICACY STUDY
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 3
Abstract
To prepare Insulin-PLGA implants and to investigate the drug release profiles. The implant tablets were prepared using PLGA as carrier and CMC-Na or HA as pore forming agent. The tablets were investigated in vivo and in vitro. SEM showed there were many discontinuous pores in the cross-section of the implants, the release of PLGA/HA implants was rapid, while PLGA/CMC-Na implants released slowly, and the hypoglycemic effect of PLGA/CMC-Na implants at the ratio of 2.5:1 was more than 108 h. Insulin-PLGA implants have good hypoglycemic effects, and can be used as a promising sustained-release preparation for insulin delivery.
Authors and Affiliations
Liandong Hu
Keywords
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