PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY OF METHICILLIN RESISTANCE STAPHYLOCOCCI ISOLATED IN A TERTIARY CARE HOSPITAL OF RURAL GUJARAT, INDIA
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 4
Abstract
Antibiotic resistance, a global concern, is particularly emerging in developing nations, including India; where the burden of infectious disease is high and healthcare spending is low. Methicillin resistant S. aureus (MRSA) and Methicillin resistant coagulase negative Staphylococci (MRCoNS), are significant pathogens of concern causing both nosocomial and community acquired infections associated with increased morbidity and mortality. A prospective cross-sectional study was therefore conducted to determine the prevalence and antimicrobial sensitivity of Methicillin resistant Staphylococci isolated at Shree Krishna Hospital, Karamsad, Gujarat, India from June 2012 to August 2014. Identification and antimicrobial susceptibility testing (AST) were carried out by VITEK 2 Compact and the Methicillin resistance was confirmed by the modified Kirby Bauer Disc Diffusion method as per CLSI- 2012 guidelines. A total of 14,415 clinical specimens were processed, of which 707 Staphylococcal isolates were obtained. Among which, 362 (51.2%) were S. aureus and 345 (48.8%) were coagulase negative Staphylococci species. The prevalence of MRSA and MRCoNS were found to be 44.8% and 78.8% respectively. Methicillin resistant isolates showed high level of resistance to Penicillin followed by Erythromycin, Levofloxacin, Co-trimoxazole, Gentamicin and Clindamycin. Low level of resistance was seen against Vancomycin. Linezolid- resistant strain of Staphylococci was not found at all in the present study. Methicillin resistant strains showed higher antimicrobial resistance as compared with Methicillin sensitive strains. Thus, a continuous surveillance of Methicillin resistant Staphylococci (MRS) is essential for proper guidance of antimicrobial therapy and to minimize the irrational use of reserved antibiotics.
Authors and Affiliations
Artee A. Tyagi| Research Scholar - M.Sc (MLT),, Dr. Sunil S. Trivedi| Prof. in Microbiology and Principal of Smt. L. P. Patel Institute of MLT- Ph.D. (Microbiology)
Keywords
Related Articles
- EP ID EP3587
- DOI -
- Views 335
- Downloads 18
A STUDY OF FORCED VITAL CAPACITY IN TYPE 2 DIABETES MELLITUS PATIENTS IN CHITRADURGA CITY, KARNATAKA
Diabetes Mellitus (DM) is a metabolic disorder precipitating micro vascular, macro vascular complications and peripheral vascular diseases. Less has been known about the after effects of diabetes on lungs. So this work...
Synthesis, Charectrisation of Novel Indole Based Derivatives Used as Medicinally Potent Agents
A large number of compounds containing indole nucleus have been patented, as chemotherapeutic agents, antimicrobial, cytotoxic, anti-inflammatory, antitumor, anti-convulsant, antitubercular and anti-HIV. A wide range of...
A Study on Role of Diagrams in the Evaluation of Learning Outcomes of Secondary Students in Life Science.
In the 20th century, revolutionary changes were brought about in the concepts and theories of biology. Biology, so much important in human life, has been renamed as ‘Life Science’ in the school curriculum. The age of old...
DETECTION OF EXTENDED SPECTRUM BETA - LACTAMASE PRODUCING E. COLI & KLEBSIELLA SPECIES CAUSING URINARY TRACT INFECTION
Extended-spectrum beta-lactamases (ESBLs) constitute a growing class of plasmid-mediated ß-lactamases which confer resistance to broad spectrum beta-lactam antibiotics. The frequency of ESBL producing strains among cli...
Performance Evaluation of PPI Dendrimer Based Valsartan and Fenofibrate Formulations.
The purpose of this investigation was to evaluate the performance of poly (propylene imine) (PPI) dendrimers, with three different drug concentrations, to be used as drug carriers. Drug–dendrimers complexes were investig...