Prevalence of acute pancreatitis in organophosphate poisoning in correlation with elevated serum amylase and lipase level in a tertiary care hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 3
Abstract
The objective is to determine the prevalence of acute pancreatitis and elevated levels of serum amylase and lipase following organophosphate poisoning. In Methodology is cross sectional study conducted at medicine department SDM Medical College during period of one year from 2014-2015. Patients of both sexes and age above 14 years admitted with positive history of organophosphate poisoning (op) were included in this study. A proforma was designed and all the collected data containing basic information of the patients, past history, physical examination and relevant investigations like complete blood count , serum amylase and lipase, serum pseudo cholinesterase, alanine amino transferase(ALT), ultrasound abdomen, CT abdomen( where needed) were documented. In Results the Among 100 patients in our study group mean age are 40±9 years, most common OP intoxication is methyl parathion. Significant symptoms seen were muscarinic in the form of secretions (87%), pin point pupil (57%), respiratory failure (21%). Marked nicotinic symptoms seen were fasciculations (14%). Significantly elevated amylase (>300u/l) was seen in 36(36%) of patients out of which 11 patients (30.55%) had significantly elevated lipase (>150) levels, confirmation of acute pancreatitis was done by ultrasonography of abdomen. In Conclusion the Elevated serum amylase and lipase levels are more frequently seen in organophosphate poisoning and are associated with acute pancreatitis as a complication. Keywords: organophosphate poisoning, acute pancreatitis, serum amylase, serum lipase
Authors and Affiliations
Dr. Mahantesh Ghaniger, Dr. Hemamalini G, Dr. Kareti Sanjana
Keywords
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