Prevalence of ESBL and Amp C producing Enterobacteriaceae in a tertiary care cancer hospital in South India with special reference to E.coli and Klebsiellapneumoniae
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background and objectives: The prevalence of ESBL and ampC producing strains among E.coli and Klebsiellapneumoniae was assessed among different samples received in Microbiology. Methods: A total of 210 non-repeating clinical isolates of E.coli and Klebsiellapneumoniae were collected from various specimens of patients with hematological malignancy over a period of 3 months (July 2016 to September 2016) prospectively in a tertiary care cancer hospital in South India. This study assessed the prevalence of ESBL and ampC and also compared the sensitivity and specificity of different phenotypic methods of ESBL and ampC detection. Results: The prevalence of ESBL and ampC β-lactamases among E.coli and Klebsiellapneumoniae was found to be 44.76% and 10.95% respectively. PCDDT (92.16%) was found to be more sensitive than DDST (83.33%) in detecting ESBL strains. The maximum ESBL production was seen in urine samples (59.18%), and that of ampC producers was seen in pus samples (20.90%). Both ESBL producers and AmpC producers had better sensitivity profile than ESBL non producers and AmpC non producers suggesting other mechanisms of resistance. Conclusion: Other studies need to be conducted to understand the mechanism of resistance to carbapenems and to know the different carbapenemases prevalent here.
Authors and Affiliations
Dr Sagila . S. G, DrSwapna R Nath
Keywords
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- EP ID EP465331
- DOI 10.9790/0853-1802042530.
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