Prevalence of Human Herpes Virus-6 (HHV-6) among Chronic HCV Patients
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 10
Abstract
Herpes viruses as CMV, EBV and HHV-6 are the most common cause severe morbidity and mortality in immunocompromised individuals. Reactivation of the virus is seen during periods of down-regulation of the immune system, such as co-infection with other pathogens. So, this study was conducted to detect the presence of Human herpes virus-6 infection in patients with chronic hepatitis C virus (HCV) infection and to point out the effect of HHV 6 -HCV co-infection on Alanine Amino Transferase (ALT) and Aspartate Amino Transferase (AST) liver enzymes. Nested polymerase chain reaction was carried out on extracted DNA from sera of both groups with hepatitis C and control group. Serological investigations were carried out as well. Fifty-three serum samples with HCV-RNA were examined, (25%) were positive HHV-6 DNA, (82%) were positive for HHV-6 IgG antibodies and (22%) were positive for HHV-6 IgM antibodies; among control specimens (18.5%) were positive for HHV-6 DNA infection, (61%) were positive for HHV-6 IgG antibodies and (14.5%) were positive for HHV-6 IgM antibodies. Moreover, the activity levels of ALT and AST liver enzymes were significantly higher in HHV-6 positive patients than that of HHV-6 negative patients. This indicates to the prevalence of HHV-6 infection is common in chronic HCV patients, that increase the severity of liver inflammation.
Authors and Affiliations
Mohamed Nabil, Waleed Abo Soad, Omar Alfarouk, Abdelbaset Mohamed Elasbali, Mohammed H Saiem Al- Dahr, Waleed S Mohamed
Keywords
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- EP ID EP484251
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