PREVALENCE OF INDUCIBLE CLINDAMYCIN RESISTANCE AMONG STAPHYLOCOCCUS AUREUS ISOLATES RESISTANT TO ERYTHROMYCIN
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 31
Abstract
BACKGROUND Clindamycin is an effective drug to treat Methicillin-Resistant Staphylococcus Aureus (MRSA). Reporting S. aureus as susceptible to clindamycin without checking for inducible clindamycin resistance may lead to therapeutic failure. Therefore, D-test is used to screen inducible clindamycin resistance. MATERIALS AND METHODS All the S. aureus isolates resistant to erythromycin were taken. Erythromycin (15 μg) disc and clindamycin (2 μg) disc were placed 15 mm apart on Mueller-Hinton agar plates as per CLSI guidelines and incubated at 37°C for 18-24 hours. Flattening of zone (D shape) around clindamycin was taken as D-test positive. RESULTS Out of 270 S. aureus isolates, 80 were resistant to erythromycin. D-test was positive in 29 isolates, out of which 23 were MRSA. These MRSA isolates were also resistant to most of the other routinely used antibiotics. This study showed that inducible clindamycin resistance is as high as 36.2% in erythromycin resistant S. aureus and 10.7% among S. aureus as such. CONCLUSION We conclude that this simple and effective method can be implemented for accurate identification of inducible clindamycin resistance in S. aureus to prevent treatment failure. Clinical laboratories should guide the clinicians about the inducible clindamycin resistance by performing D-test routinely and prevent misuse of antibiotics.
Authors and Affiliations
Syed Asim M, Prajna Sharma, Anita K. B, Swathi V, Narendra Nayak
Keywords
Related Articles
- EP ID EP217970
- DOI 10.18410/jebmh/2017/355
- Views 104
- Downloads 0
A PROSPECTIVE STUDY ON ASSESSMENT OF VISUAL FUNCTION OF TRUCK DRIVERS TRAVELLING ON NATIONAL HIGHWAY
BACKGROUND Truck drivers commonly referred as truckers, provide essential services to industrialized societies and are also responsible for inspecting all their vehicles for safe operation. They are the most responsible...
ASSESSMENT OF EFFECT OF MDR-TB/TB ON SOCIAL, FUNCTIONAL AND ECONOMIC WELL BEING OF PATIENTS – A CROSS SECTIONAL STUDY
CONTEXT: Tuberculosis is a contagious disease with social stigma attached to it. Various problems which are social and economic in nature are faced by TB patient. Therefore, it is essential to explore the overall effect...
COMPARATIVE STUDY ON THE EFFECT OF ADDITION OF POTASSIUM CHLORIDE TO BUPIVACAINE ON THE ONSET TIME AND DURATION OF BRACHIAL PLEXUS BLOCK
Background and objectives: Regional anaesthetic technique such as brachial plexus block by supraclavicular approach is widely used for upper limb surgeries. This study compared the addition of potassium chloride to bupiv...
FLAP CLOSURE FOR GLUTEAL PILONIDAL SINUS- IS IT AN ECONOMICALLY VIABLE OPTION?
BACKGROUND Flap closure technique for sacrococcygeal pilonidal sinus disease has been conclusively shown to be effective in relieving recurrence rate in many studies, but it is expensive and difficult to perform. Purpose...
A STUDY TO ESTABLISH ASSOCIATION OF HYPERGLYCEMIA AND INPATIENT MORTALITY IN PATIENTS WITH UNDIAGNOSED DIABETES MELLITUS
The aim of this study was to establish the prevalence, survival, and outcome of patients presented with in-hospital hyperglycemia in which there is prior history of diabetes and without a history of diabetes. We reviewed...