Prevalence of Multidrug-resistant, Extensively Drug-resistant, and Pandrug-resistant Pseudomonas Aeruginosa in Different Clinical Samples in Tertiary Care Center
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Antibiotic resistance is one of the alarming issues, affecting human health P. aeruginosa is a prototype of “multidrug-resistant pathogen” and is recognized for its ubiquitous distribution, advanced antibiotic resistance mechanisms, and nosocomial infections.. The organism is classified into various phenotypes based on the drug resistance pattern, namely, drug-resistant (DR), multi-DR (MDR), extensively DR (XDR), and pan-DR (PDR). Methods: This cross sectional study was conducted in Microbiology Department of Agartala Govt Medical college under GBP hospital , from 1st January 2016 to31st December 2016. Clinical specimens were collected from different clinical departments of GBP hospital. Clinical isolates were identified by standard and specific microbiological methods. The antibiotic susceptibility pattern was determined by Kirby Bauer Disc diffusion method. Clinical and Laboratory Standards Institute (CLSI) guidelines were used to determine the results. Results: The frequency of MDR P. aeruginosa isolated from different clinical specimens was found to be43.43%. Antibiotic resistance studies revealed that 50.51% of P. aeruginosa isolates were DR, and 6.06% were XDR phenotype. None of the strains showed PDR phenotype. Amikacin was found to be the most effective antibiotic, followed by Carbapenem group of drugs . Conclusion: Our data revealed a high prevalence of DR phenotypes of P. aeruginosa in the total isolate of P aeruginosa. There is an urgent need to resolve the issue by taking some preventive measures. Combined efforts of health care professionals and researchers are required to educate people about the proper use of antibiotics and other infection control measures.
Authors and Affiliations
Arundhati Jamatia
Keywords
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