Prevention of contrast-induced nephropathy in patients undergoing percutaneous coronary interventions in everyday clinical practice
Journal Title: Archives of Medical Science - Year 2006, Vol 2, Issue 4
Abstract
Introduction: Contrast nephropathy is a potentially serious complication of PCI, particularly in patients with chronic kidney disease – CKD. Material and methods: Assessment of the effects of preventive measures on the prevalence of contrast-induced nephropathy in 529 consecutive patients with coronary artery disease undergoing percutaneous coronary interventions. In all the patients 24 h before PCI all nephrotoxic drugs (NSAIDs, diuretics, biguanidine derivatives in diabetic patients) were withdrawn and doses of ACEi were either withdrawn or reduced. Results: Only 27.4-47.7% of patients with normal serum creatinine at admission had eGFR over 90 ml/min according to Cockcroft-Gault and MDRD formulae. In 39 patients we observed a rise in serum creatinine of more than 25% relative to baseline. More frequently they were females, hypertensive, PCI time was longer and contrast volume was higher. In 5 pts (0.9%) acute renal failure was observed (rise in creatinine more than 0.5 mg/dl relative to baseline). These patients received more contrast agent (p
Authors and Affiliations
Hanna Bachórzewska-Gajewska, Jolanta Małyszko, Ewa Sitniewska, Jacek Małyszko, Sławomir Dobrzycki
Keywords
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