Prevention of microvascular diabetic complications by fenofibrate
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2015, Vol 32, Issue 2
Abstract
Microvascular complications are common in patients with type 2 diabetes mellitus. According to the results of recent studies (ADVANCE, VADT, ACCORD), achievement of glycemic control and blood pressure targets have only minor impact on microvascular complications. In 2005, the FIELD study showed that fenofibrate reduces the need for laser treatment of retinopathy and slows the progress of renal dysfunction. Furthermore, the FIELD eye sub-study concluded that fenofibrate reduces the risk of retinopathy and its progression. A later analysis of the FIELD study concluded that fenofibrate also reduces the risk of non-traumatic amputation in patients with diabetes. The ACCORD study produced similar results, showing that fenofibrate use significantly reduced the progression of retinopathy and albuminuria, independently of its effect on lipids. The results of these studies confirm the important role of fenofibrate in the prevention of significant microvascular diabetic complications
Authors and Affiliations
A. KOUTSOVASILIS, S. PAPPAS
Keywords
Related Articles
- EP ID EP163443
- DOI -
- Views 83
- Downloads 0
Σφυγμός: φλεβικός ή αρτηριακός;<br /> Φιλόσοφος διορθώνει ιατρόν!<br />
Biological agents and hepatitis
Hepatitis B virus (HBV) reactivation is a serious but preventable clinical complication of immunosuppression, with substantial morbidity and mortality, caused by immune reconstitution of specific immunity to specific vir...
Prognostic stratification and minimal residual disease assessment in Acute Myeloid Leukemia by molecular techniques
Currently cytogenetic analysis at diagnosis provides the most important information about the prognosis of Acute Myeloid Leukemia (AML), with categorization into three distinct prognostic groups (favorable, intermediate...
Acute aortic dissection
No abstract available
Percutaneous exposures among health care workers in a Greek tertiary hospital
OBJECTIVE Percutaneous exposures (PCE) constitute a major occupational health problem for health care workers (HCW). Data on the incidence rate of PCE from Greek hospitals are sparse. The epidemiology of PCE was investig...