Preventive and therapeutic effects of berberine on liver diseases and its mechanism
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Berberine is an antipyretic and detoxicating drug commonly used in clinical practice， and it is currently used for the routine treatment of gastrointestinal diseases such as bacterial gastroenteritis and diarrhea. However， several recent studies have shown that berberine can exert a therapeutic effect on the diseases such as autoimmune hepatitis， viral hepatitis， nonalcoholic fatty liver disease， and liver cancer by regulating the AMPK and TGF-β pathways and altering the composition of intestinal flora. This provides new drugs for the treatment of these diseases， expands the potential indications of berberine， and provides clues for the follow-up research and development of similar drugs. This article summarizes the therapeutic effect and mechanism of berberine on various liver diseases， in order to provide a reference for effective clinical application.
Authors and Affiliations
Huili WANG, Wenhao QIN, Dangdang YANG, Yaqian NING, Shan LIN, Songlin DAI, Bing HU
Keywords
Related Articles
- EP ID EP753495
- DOI 10.12449/JCH241130
- Views 27
- Downloads 1
Effectiveness of fibrosis-4 versus aspartate aminotransferase-to-platelet ratio index in evaluating liver fibrosis degree in patients with chronic HBV infection
[Objective] To investigate the performance of fibrosis-4 （FIB-4） versus aspartate aminotransferase-to-platelet ratio index （APRI） in predicting advanced liver fibrosis and disease progression in patients with chronic...
Clinical efficacy of liver venous deprivation versus portal vein embolization in treatment of liver cancer with insufficient residual liver volume： A Meta-analysis
[Objective] To systematically evaluate the efficacy and prognosis of liver venous deprivation （LVD） versus portal vein embolization （PVE） in the treatment of hepatic malignancies with insufficient residual liver volu...
The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies
Non-alcoholic fatty liver disease （NAFLD） is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis， liver cirrhosis， and hepato...
Research advances in traditional Chinese medicine syndromes of fatty liver disease
Fatty liver disease can be classified into alcoholic fatty liver disease and nonalcoholic fatty liver disease based on etiology， and it has become the most important liver disease worldwide. Due to the differences in th...
Effect of interleukin-22 on hepatic stellate cell activation and its mechanism
[Objective] To investigate the effect of interleukin-22 （IL-22） on the activation of hepatic stellate cells （HSCs） and its mechanism. [Methods] The human HSC LX-2 cells were selected for the study， and the LX-2 cell...