Primary hyperaldosteronism. Mechanisms and consequences of pathological influence on an organism (review of literature)
Journal Title: Міжнародний ендокринологічний журнал - Year 2019, Vol 15, Issue 4
Abstract
The work is based on the analysis of world literature data on primary hyperaldosteronism. The data on mechanisms of pathological influences of excessive autonomous aldosterone secretion on the body systems are given. The ways of excessive aldosterone influence on the cardiovascular and nervous system, kidneys, quality and life expectancy are revealed. It is shown that aldosterone activates specific intracellular genomic and non-genomic pathways of influence on the cardiovascular system and induces the development of cardiofibrosis, atrial fibrillation and heart failure. Attention is drawn to the fact that hyperaldosteronism is a cause of the development of metabolic syndrome, deterioration in quality of life and reduction of life expectancy.
Authors and Affiliations
V. А. Shidlovsky, А. V. Shidlovsky, V. V. Kravtsiv
Keywords
Related Articles
- EP ID EP630818
- DOI 10.22141/2224-0721.15.4.2019.174824
- Views 71
- Downloads 0
Use of Neurovitan in the Treatment of Endocrine Polyneuropathy
Neurovitan may be the drug of choice in the implementation of complex therapy of neurotropic vitamins in patients with endocrine pathology. Objectiv: to study the effectiveness of Neurovitan in the complex treatment of...
Dynamics of Hormonal and Immunological Indexes during Conservative Treatment of Patients with Diffuse Toxic Goiter
The dynamics of structural and functional state of thyroid gland was studied, as well as the levels of antithyroid antibodies in patients with diffuse toxic goiter (DTG) during long-term treatment with thyrostatic agents...
Diagnostic Markers and the Method of Predicting Chronic Pancreatitis Development in Patients with Type 2 Diabetes Mellitus
The purpose of the present study was to determine the diagnostic markers and the method of predicting of chronic pancreatitis in type 2 diabetes mellitus patients. Materials and methods. A total of 94 patients (33 males...
Features of Thyroid Functional State in Patients with Type 2 Diabetes Mellitus and Obesity
We have observed 55 patients with diabetes mellitus (DM) type 2 and obesity without signs of thyroid function abnormality, as well as 60 patients with DM type 2 and obesity combined with overt or subclinical hypothyroidi...
PCNA expression as a marker of proliferation in benign and highly differentiated malignant tumors of the human thyroid gland (literature review and clinical case)
Determining of the proliferative potential of tumor cells is an important task for the diagnosis of thyroid cancer. Therefore, a search for markers characterizing the state of proliferative processes is necessary. Prolif...