PRODUCTION OF NOVEL ANTIFUNGAL COMPOUNDS FROM ACTINOMYCETES ISOLATED FROM WASTE DUMP SOIL IN WESTERN UGANDA
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 5
Abstract
Drug resistant and opportunistic organisms are a problem to medical health due to the fact that most of the drugs that were used are now not effective. Currently there is a need to search for new drugs that can enhance the control of these organisms. Actinomycetes and their secondary metabolites can be used as such drugs. This study was designed to isolates actinomyctes producing novel anti-fungi from waste dump soil in Western Uganda. Fifty six (56) actinomycetes were isolated from 22 dump soil samples. All isolates were screened using modified spektra - plak methods against Candida albicansATCC1023, Penicillium Spp, Aspergillus Spp Fusarium Spp and Rhizophus Spp. Eight (14.29%) isolates shows antifungal activity to one test fungi during the screening. Two isolate (KBRWDSa (FR) and KBMWDSb6) showed activity to all test fungus. The second screening was carried out by first growing all Fifty six isolates (56) in broth and their supernatant tested for activity using agar well method. Eleven (19.64%) of these isolates showed activity to one test fungi with mean zone of inhibition 5.33 to 29.69mm. Isolate KBMWDSb6 showed a broad spectrum activity. The remaining broths were extracted using ethanol. The ethanol extract at concentration of 2.5mg/ml was also tested for antifungal activity using agar well diffusion method. Thirteen (23.21%) showed activity against one test fungi with mean zone of inhibition 6.33 to 30.67mm. The findings showed that some of these isolates had antifungal activity.
Authors and Affiliations
Adamu Almustapha Aliero
Keywords
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