Profile of Autoantibodies in Adults With Primary Inmune Thrombocytopenia in an Institution of Bogota.
Journal Title: Revista Cuarzo - Year 2019, Vol 25, Issue 1
Abstract
Introduction. A platelet count below 150,000 and normality in the remainder of the blood count are necessary to consider primary immune thrombocytopenia (ITP). Although the pathogenesis has not been fully elucidated, a combination of events characterized by increased destruction of platelets mediated by autoantibody production has been described. Previous publications have reported the presence of Autoantibodies in patients with ITP, Anticardiolipin antibodies (AAC) (75%), antinuclear antibodies (ANAS) (33,3%) and Antiphospholipid antibodies (AAF) (28,5%). Research in our country describe demographic, social characteristics and response to treatment of patients with ITP, but there are no descriptions of the presence of autoantibodies. Objectives. To identify the prevalence of autoantibodies in PTI in the San Rafael clinical university hospital of Bogota, in the period 2008 - 2012. Methods. A descriptive observational study was carried out. The population was adults of both sexes older than 16 years old with diagnosis of Primary Immune Thrombocytopenia (ITP) at the San Rafael clinical university hospital of Bogotá between 2008-2012. Patients with another confirmed diagnosis as a secondary cause of thrombocytopenia were excluded. A total of 723 medical records were reviewed, of which 72 met the inclusion criteria. Results. 72 medical records were analyzed, 69,6% were women, the positive autoantibodies were the ANAS with 59,7% followed by the antibodies Anticardiolipin (ACA) IgM with 18% and ACA IgG with 16,6%, the lupus anticoagulant was positive in 9,7%. The positive ANAS corresponded to titers> 1: 160 and the mottled pattern was the most frequent with 41,8%, of the patients with a platelet count lower than 50,000, 45% had a positive lupus anticoagulant. In 30,5% of the total cases, some complication occurred, 59% were due to bleeding. Conclusions. In this study we found that the most frequent antibodies were ANAS and Anticardiolipin Antibodie
Authors and Affiliations
Solorzano Ramos, C. , Mora, J. , Ovalle, A. , López, V. , Romero, P. , & Beltrán Ostos, A.
Keywords
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- EP ID EP694660
- DOI https://doi.org/10.26752/cuarzo.v25.n1.346
- Views 127
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