Profile of Cardiovascular Risk Factors in Ischemic Heart Disease in Patients with Normal and Impaired Carbohydrate Metabolism
Journal Title: Міжнародний ендокринологічний журнал - Year 2016, Vol 3, Issue 75
Abstract
Aim of investigation — to conduct the comparative analysis of profile of general population cardiovascular risk factors in patients with ischemic heart disease (IHD) on a background of normal and impaired carbohydrate metabolism. Materials and methods. In order to evaluate the incidence of different forms of IHD depending on the state of carbohydrate metabolism, the following groups were formed: group I — 113 patients with type 2 diabetes mellitus (DM), group II — 69 persons with impaired glucose tolerance (IGT) and group III — 60 individuals without carbohydrate metabolism disorders. In future, subgroups of patients with IHD were formed from these groups to compare cardiovascular risk factors profile: 32 patients with type 2 DM and IHD, 14 persons with IGT and IHD, 10 individuals with IHD without carbohydrate metabolism disorders. Results. Silent myocardial ischemia (SMI) was detected in 21 (18.6 %) patients with type 2 DM, in 5 (7.2 %) persons with IGT and in 2 patients (3.3 %) with a normal carbohydrate metabolism. From indexes that characterize cardiovascular risk factors and have a high prognostic value in relation to the presence of SMI, the combination of such predictors, as sex, type 2 DM duration, family history of IHD and/or type 2 DM, the content of HbA1c, high density lipoproteins, the presence of hypertrophy and type 1 left ventricular diastolic dysfunction, have the greatest ability to predict the development of the discussed pathology in patients with type 2 DM. Conclusions. A profile of general population risk factors of cardiovascular diseases in patients with type 2 DM and IHD is most unfavorable. In persons with early violations of carbohydrate metabolism and with normal carbohydrate metabolism, it does not differ statistically significant. Patients with type 2 DM and SMI, as compared to the patients with type 2 DM without IHD, have statistically significantly more severe violations of general population risk factors for cardiovascular disease (smoking, family history of IHD and/or type 2 DM, disorders in the hemostasis system, dyslipidemia), as well as additional risk factors (hyperglycaemia, diabetic nephropathy, left ventricular dysfunction).
Authors and Affiliations
І. V. Cherniavska
Keywords
Related Articles
- EP ID EP205384
- DOI -
- Views 78
- Downloads 0
Male hypogonadism (Part 1)
The first part of the review presents the current data on the prevalence of male hypogonadism, methods of diagnosing different forms of hypogonadism, describes the clinical manifestations of the most common forms of this...
Central Diabetes Insipidus
The lecture presents modern data on epidemiology, etiology, pathogenesis, diagnosis and treatment of central diabetes insipidus.
Laboratory Aspects of Hyperprolactinemia Diagnosis
The paper presents the modern laboratory aspects of diagnosing hyperprolactinemia and monitoring the effectiveness of treatment according to the Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinica...
Study of Features of Pregnancy in Women with Onset of Diabetes Type 1 in Prepubertal Period
We studied course of pregnancy in 22 patients with onset of diabetes type 1 in the prepubertal period. It is found that the need for insulin, depending on the duration of pregnancy, varied: decreased in the first trimest...
Clinical Case of the Combined Course of Diffuse Toxic Goiter and Autoimmune Ophthalmopathy
The article presents the experience of treating a patient with diffuse toxic goiter in conjunction with autoimmune ophthalmopathy, about what the patient took thyrostatic drugs, β-blockers, systemic glucocorticoids. On t...