Profile of Neurocognitive Impairment in Individuals Coinfected with Human Immunodeficiency Virus and Hepatitis C Virus: Meta-analysis and Meta-regression
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 19, Issue 10
Abstract
HIV and HCV are neurotrophic viruses with great potential to cause neurocognitive impairments (NCI). Yet, results of neuro studies among Coinfected individuals are still inconclusive. This study pooled estimates to define the neurocognitive profile and neuroepidemiology of Coinfection in relation to monoinfection. Data from the qualified studies was grouped in to seven neurologic domains to yield weighted average effect sizes (WAES) which were pooled together in meta-analyses. Further assessments were meta-regression analysis, sensitivity analysis and computation of heterogeneity diagnostic indices. From eleven studies the pooled estimates showed that only the Coinfected group had a medium effect size (ES) in speed of information processing (SIP). Other neurologic domains exhibiting a medium ES across all the study groups were executive function (EF) and attention/working memory. These neurocognitive deficits epidemiologically translates in to NCI prevalence of 47% among Coinfected group who were also twice more likely to be neurocognitively impaired compared to HIV monoinfection group. Despite substantial heterogeneity, Kernel density plot of WAES approximates to normal distribution making publication bias unlikely. Coinfection is associated with deficit in SIP, EF and attention/working memory with substantial risk of global NCI underscoring the need for medical and psychosocial interventions to improve the lives of affected individuals.
Authors and Affiliations
Ahmad M. Yakasai
Keywords
Related Articles
- EP ID EP311166
- DOI 10.9734/BJMMR/2017/30780
- Views 80
- Downloads 0
Secretor Status and Phenylthiocarbamide (PTC) Taste Perception are Risk Factors for Pulmonary Tuberculosis
Aim: To examine whether or not non-secretion of ABH substances and non-tasting of PTC are risk factors exhibiting positive interactions for tuberculosis. Methodology: A total of 210 individuals comprising 110 tuberculos...
Application of Working Memory Computerized Test (WMCT) for Working Memory Deficit in Patients with Parkinson Disease
Introduction: This study deals with the study of memory rehabilitation in patients with Parkinson's disease. Measures included systematic rehabilitation techniques for the recovery of symptoms and had no errors. However,...
Is It Prudent to Screen the Thyroid before Initiating Treatment for Acromegaly?
Aim: To present a case of acromegaly with coexisting thyrotoxicosis and to emphasize the relevance of screening the screening the thyroid before initiating treatment for thyrotoxicosis. Presentation of the Case: A 55-yea...
Factors Influencing Maternal Acceptance of Human Papillomavirus Vaccination for Their School-Aged Daughters in Fukuoka Prefecture, Japan
Aims: The aim of this study was to elucidate the factors that influence maternal acceptance of human papillomavirus (HPV) vaccination for their school-aged daughters. Study Design: The survey was cross-sectional and cond...
Health Care Financing and Budgetary Allocation in Ondo State
Funding of the health care sector in Nigeria is faced with enormous challenges that must be overcome if quality and effective health care service is to be made available to the people. While health care research has focu...