Prognostic Analysis of Neutrophil/Lymphocyte Ratio and Thrombocyte/Lymphocyte Value Before Trimodal Treatment in Invasive Bladder Cancer
Journal Title: Istanbul Medical Journal - Year 2020, Vol 21, Issue 2
Abstract
Introduction: To evaluate whether neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios have prognostic value in patients undergoing bladder conserving treatment (trimodal therapy). Methods: A total of 40 patients receiving trimodality treatment for invasive bladder cancer were included in the study retrospectively. NLR and PLR were obtained for every patient before trimodality treatment was applied. We investigated whether NLR and PLR values had prognostic value for survival. Results: Gender, age, T stage, Histologic grade, radiotherapy dose, NLR and PLR values were evaluated in bladder cancer patients receiving trimodal therapy. In the receiver operating characteristic analysis, the optimum cut-off value for NLR was found to be 3.2 (sensitivity 71.4%, specificity 65.2% p<0.025). Area under the curve (AUC): 0.717, confidence interval (CI) 95% (0.557-0.877), the optimum cut-off for PLR was found as 152.25 (sensitivity 78.1%, specificity 64.2%, p<0.006), AUC: 0.764, CI 95% (0.610-0.917). Survival analysis showed that disease-free survival was 52.36±6 months and statistically significant in patients with an NLR value greater than 3.2 (p=0.023). PLR value above 152.25 was found to be an independent risk factor for disease-free survival (52.8±6.1 months) and overall survival (50.6±7.2 months) (p=0.043, p=0.011, respectively). Conlusion: NLR and PLR before trimodal treatment in invasive bladder cancer patients may be considered as a prognostic factor for disease progression. NLR and PLR values should be taken into consideration when deciding on trimodal treatment.
Authors and Affiliations
Berrin İnanç, Özlem Mermut
Keywords
Related Articles
- EP ID EP685064
- DOI 10.4274/imj.galenos.2020.57984
- Views 154
- Downloads 0
A Retrospective Analysis of Patients Receiving Teleradiology Consultations for Computed Tomography in the Emergency Department
Introduction: Teleradiology plays an essential role in the accurate and prompt diagnosis of patients in the emergency department (ED). This study aimed to analyze some factors affecting the use of teleradiology in EDs....
Recurrent Angioedema with Abdominal and Genital Involvement in Childhood: Hereditary Angioedema Type 2 Disease due to C1 Inhibitor Functional Deficiency
Hereditary angioedema is a rare disorder characterized by recurrent angioedema attacks due to C1 inhibitor antigen or functional deficiency. Here, two cases with recurrent swelling on extremities, genital organs and face...
Pyogenic Granuloma: Retrospective Analysis of Eleven Cases with Literature Data
Introduction: The aim of the present study was to determine the demographic characteristics of patients undergoing surgery for pyogenic granuloma (PG) in our clinic and to discuss them with the literature data. Methods:...
The Values of First-trimester Maternal Serum Markers in Predicting Poor Obstetric Outcomes
Introduction: The effects of pregnancy-associated plasma protein A (PAPP-A) and maternal serum free beta-human chorionic gonadotropin (β-hCG), which are first trimester maternal serum markers, on assisting in the diagnos...
The Usefulness of Endoscopic Retrograde Cholangiopancreatography at Preoperative or Postoperative Cystic Echinococcus Patients
Introduction: The aim of this study was to evaluate the efficacy of endoscopic retrograde cholangiopancreatography (ERCP) at cystic echinococcus (CE) patients in the preoperative or postoperative period. Methods: Hepati...