Prognostic Factors for Outcome of Childhood Lymphoblastic Leukemia At Cancer Centers in Jeddah
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Background: Pediatric acute lymphoblastic leukemia (ALL) is disease of considerable interest, partly due to its high mortality rate if left untreated, and partly due to its high survival rates when properly treated. Early identification of the prognostic factors that will determine the long-term outcome of the disease is of crucial importance, as aggressive management of these factors may improve the outcome. Objectives: To identify the prognostic indicators of ALL in Saudi Arabia and to determine outcome and the 5 and 10-year survival rates of the disease. Subjects and Methods: 149 children diagnosed with ALL between 2004-2006 were recruited from 3 cancer-treating centers in Jeddah. Demographic, clinical, laboratory and outcome data were collected retrospectively from medical records at these centers. Results: Using Kaplan Meier log-Rank test, females had higher survival probability at 5 and 10 years (0.865, 0.844) in comparison to males (0.631, 0.573) (p<0.0008). Splenomegaly, hepatomegaly, abnormal Cytogenetic and CNS involvement worsened survival probability at 5 and 10 years (p=0.002, 0.004, 0.028 and 0.048 respectively). Initial WBC<50000μ/L and LDH level<300U/L significantly enhanced survival (p = 0.003 and < 0.0001, respectively). Using Cox PH model, Hazard ratios of CNS disease, Cytogenetic features, high WBC>50000μ/L, and LDH level>300U/L were 3.46, 5.64, 8.84 and 15.0 respectively. The mean 5 and 10-year survival probabilities were 0.736 and 0.688, respectively. Conclusions: Certain factors had a negative impact on five and ten-year survival probability in children with ALL in Jeddah, namely male sex, abnormal cytogenetic, splenomegaly, hepatomegaly, CNS involvement, initial WBC>50000 μ/L, and initial LDH level >300 U/L.
Authors and Affiliations
Asheqah M. Al-Balwi, Sleem Binmahfoz, Rajaa M. AL-Raddadi, Hassan A. Al-Trabolsi, Abdullah A. Baothman, Mohamad Hasan Qari
Keywords
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- EP ID EP548772
- DOI 10.21276/ijmrp.2017.3.6.039
- Views 111
- Downloads 0
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