PROGNOSTIC IMPORTANCE OF HYPONATRAEMIA IN ACUTE ST-ELEVATION MYOCARDIAL INFARCTION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 20
Abstract
BACKGROUND In patients with heart failure, hyponatraemia has been shown to be a predictor of cardiovascular mortality. In fact, the neurohormonal activation that accompanies acute myocardial infarction is similar to that which accompanies heart failure. Hence, we aimed to investigate the prognostic importance of hyponatraemia in the setting of acute ST-elevation MI and to determine its usefulness in predicting short-term survival. MATERIALS AND METHODS This is a prospective observational study of 100 patients presenting with acute ST-elevation myocardial infarction admitted in ICCU, Department of Medicine, KIMS, Hubli, during the period of 1st December 2009 to 30th November 2010 were studied. Detailed history and clinical examination has been done. Plasma sodium concentrations were taken on admission and at 24, 48 and 72 hours thereafter. The primary end point has been taken as mortality within 30 days following myocardial infarction. RESULTS In this study, significant proportion of patients who presented with acute ST-elevation myocardial infarction were having hyponatraemia at time of admission or developed hyponatraemia after admission. The odd’s ratio for 30-day mortality was found to be high in the hyponatraemic groups compared to normal group. There was a significant linear relationship between severity of hyponatraemia and mortality. Multivariate analysis was done, which showed hyponatraemia on admission or early development of hyponatraemia as a significant independent predictor of 30-day mortality. CONCLUSION In this study, we concluded that presence of hyponatraemia on admission or early development of hyponatraemia in patients with acute ST-elevation myocardial infarction is an independent predictor of 30-day mortality. Plasma sodium levels may serve as a simple marker to identify patients at risk.
Authors and Affiliations
Adithya Udupa K, Aniruddha Udupa K
Keywords
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- EP ID EP431411
- DOI 10.14260/jemds/2018/564
- Views 69
- Downloads 0
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