Prognostic Significance of Hematological and Biochemical Parameters in Multiple Myeloma
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Background: Multiple myeloma accounts for 1% of all types of malignancies and about 10 % of hematologic malignancies. Several clinical and laboratory variables help us to determine the prognosis of the disease. The present study is aimed at analyzing the various clinical presentations and studying hematological and biochemical parameters in determining prognosis in Myeloma. Materials and Methods: 100 patients diagnosed as Multiple Myeloma who registered at hematology laboratory in a tertiary health care centre over a span of 3 years were studied. Clinical & radiological findings were recorded. Hematological & biochemical parameters were analyzed and compared between alive and expired patients. Based on the International Staging System (ISS) for multiple myeloma patients were staged as I, II & III and assessed correlation with prognosis. Statistical analysis was done by Student T test & ANOVA test. Results: Most common clinical presentation was bone pain. Among the variables considered, serum creatinine and serum Beta 2 microglobulin showed statistically significant correlation with prognosis. The mean value of Serum creatinine and serum beta 2 microglobulin were 3.03 mg/dl and 5.8 mg/L respectively in expired patients. Staging by International Staging System was found to have good correlation with prognosis. Conclusion: Serum beta 2 microglobulin and serum creatinine were found to be statistically significant and reliable prognostic indicators. Staging by International Staging System with prognostic correlation was also achieved by the present study.
Authors and Affiliations
Dr Roshny Jacob
Keywords
Related Articles
- EP ID EP529744
- DOI -
- Views 100
- Downloads 0
Arrythmiasin Athletes: What Is New?
Sports seem to as old as mankind. Athletic performances, though are of proven long term benefits, tests the capacity of human mind and body. Arrhythmias that occur during or shortly after exercise are labelled as Exercis...
Sepsis in Pregnancy: Some Old verses New Inclusions
Abstract
A Cross- Sectional Study to Assess the Extent of Helicopter Parenting in Adolescent Age Group
“Helicopter parenting “or cosseting parent is a term used to describe a phenomenon of a growing number of parents, who pays extremely close attention and obsessed with their children’s success particularly at areas of de...
Teaching Communication Skills to Medical Undergraduates -Showing the Right Path
A structured training in communication skills is not given in most medical colleges in India although Medical council has made it compulsory. Studies on its effectiveness are few in India & abroad. This study is an educa...
Diagnostic accuracy of Multidetector Computed Tomography in Evaluation of Blunt Abdominal Injury
Introduction: Rapid detection of life-threatening abdominal injuries and promptly initiating appropriate care reduces trauma related mortality and morbidity. Accurate clinical evaluation may be difficult in altered consc...