Prognostic Utility of Procalcitonin, NT-ProBNP and Sofa Score in ICU Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Introduction: The availability of appropriate diagnostic tests and treatment is more important in the first few hours of admission in Intensive Care Unit (ICU), where the patients are more likely to be unstable and require utmost care. Thus, it is necessary to identify those patients who are at risk, either through readily available laboratory biomarkers or clinical criteria or both. Aims and objectives: To evaluate the prognostic utility of Procalcitonin (PCT), NT-proBNP and Sequential Organ Failure assessment (SOFA) score in patients admitted to ICU. Materials and Methods: 56 consecutive patients admitted to the ICU were enrolled for the study . The study protocol was approved by the institutional ethics committee. Written informed consent was obtained from the patient or patient’s first degree relatives. They were classified into sepsis or non-sepsis group according to SEPSIS-3 criteria. Demographic and clinical data including age, gender, preexisting co- morbidities, presence of ventilatory and vasopressor support, duration of ICU stay, SOFA score and outcome were recorded. NTproBNP and PCT were estimated by electrochemiluminescent immunoassay. Data were analyzed using MedCalc software. Logistic regression analysis was done to determine the independent predictors of outcomes. A Kaplan-Meier curve was used to illustrate the cumulative proportions of survival. A two-tailed 𝑃 < 0.05 was considered statistically significant. Results: Median of Age, PCT and SOFA score were higher in sepsis group in comparison to non sepsis group and is statistically significant (P=0.04, 0.0001, 0.0002 respectively) where as only PCT and SOFA score are higher in the non survivor group (P=0.0007 for both) compared to survivor group. Conclusion: Markedly elevated levels of PCT were observed in Sepsis and Non survivor groups. NTproBNP is found to be an independent predictor of morbidity indicating the requirement of vasopressor and ventilator support. SOFA score is an independent predictor of mortality.
Authors and Affiliations
Ratna Deepika Mattaparthi, N. N. Sreedevi, K. S. S. Saibaba, M. V. S. Subba Laxmi, M. Vijaya Bhaskar, J. Pradeep Kumar, Noorjahan M
Keywords
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- EP ID EP375229
- DOI 10.9790/0853-1705112328.
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