Prognostic Value of miRNA-155 Expression in B-Cell Non-Hodgkin Lymphoma
Journal Title: Turkish Journal of Hematology - Year 2017, Vol 34, Issue 3
Abstract
Objective: MicroRNA-155 (miRNA-155) resides within the B-cell integration cluster gene on chromosome 21. It can act either as an oncogene or as a tumor-suppressor gene, depending on the cell background in which miRNA-155 is performing its specific target gene controlling function. Therefore, the aim of this study was to investigate miRNA-155 expression in patients with B-cell non-Hodgkin lymphoma (NHL) and its relation to disease prognosis in diffuse large B-cell lymphoma (DLBCL) patients. Materials and Methods: Reverse transcription-polymerase chain reaction assay was performed to evaluate the expression levels of miRNA-155 in 84 patients with newly diagnosed B-cell NHL and 15 normal controls. Results: Compared with normal controls, miRNA-155 expression was significantly upregulated in patients. Moreover, higher levels of miRNA-155 were associated with the presence of B symptoms, involvement of extranodal sites, and high Eastern Cooperative Oncology Group (ECOG) score. Higher levels of miRNA-155 in DLBCL were associated with non-germinal B-cell-like type, the presence of B symptoms, involvement of extranodal sites, and higher International Prognostic Index (IPI) and ECOG scores. Only the high IPI score and high miRNA-155 expression indicated a higher risk of lower event-free survival using multivariate Cox regression analysis. Our data demonstrated that the expression of miRNA-155 was upregulated in newly diagnosed B-cell NHL patients. miRNA-155 is expressed at a lower level in GCB-subtype DLBCL. Low IPI score and miRNA-155 expression were predictors of longer event-free survival. Conclusion: Despite contradicting literature reports, the current findings suggest the potential value of miRNA-155 as a biomarker of prognosis and monitoring in B-cell NHL, and especially that of the DLBCL type.
Authors and Affiliations
Ahmed M. L. Bedewy, Shereen M. Elmaghraby, Ahmed A. Shehata, Noha S. Kandil
Keywords
Related Articles
- EP ID EP228558
- DOI 10.4274/tjh.2016.0286
- Views 91
- Downloads 0
Post-Partum Yumurtalık Ven Trombozu: Enfeksiyon ve Faktör V Leiden Mutasyonunun Birleşik Etkisi
Evaluation of Endocrine Late Complications in Childhood Acute Lymphoblastic Leukemia Survivors: A Report of a Single-Center Experience and Review of the Literature
Objective: Improvement in long-term survival in patients with acute lymphoblastic leukemia (ALL) in childhood has led to the need for monitorization of treatment-related morbidity and mortality. In the current study, we...
Antiphospholipid Antibodies and Systemic Scleroderma
Non-Leukemic Granulocytic Sarcoma Presenting with Multiple Skin Nodules and a Retroperitoneal Mass
Here we present a case of multiple granulocytic sarcomas with monocytic differentiation involving the skin and retroperitoneal area.
The Relationship Between Hematological Findings and Coronary Artery Aneurysm in Kawasaki Disease