Prognostic Value of p53 Expression in Intestinal Neoplasms - a Study in a Tertiary Health Care Centre
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
Colorectal cancer is one of the most common tumours of the world with the varying distribution. Though small intestine is an uncommon site for tumour, it accounts for significant number of gastro-intestinal malignancies. Pathological assessment of the resected specimen is mandatory for assessing the postoperative outcome and the rationale for adjuvant therapy. Among the various prognostic factors, Mutation of the p53 tumour suppressor gene, plays an important role in the progression of colorectal carcinoma and so it represents a clinically useful marker of prognosis. The present study evaluates the role of p53 in intestinal neoplasms by assessing its level of expression and to correlate the level of p53 expression with the stage of the colorectal adenocarcinomas so that its prognostic value in colorectal adenocarcinomas can be calculated.
Authors and Affiliations
Arputham Arunachalam1, Babiya Infant Arockiasamy
Keywords
Related Articles
- EP ID EP389742
- DOI 10.9790/3008-1203061420
- Views 92
- Downloads 0
Phytochemical Composition and Fungicidal Potential of Moss Philonotis Revoluta against Spore Germination Process of Fungus Helminthosporium Turcicum
Information about the occurrence of phytochemicals which act as antibiotic substances in bryophytes and the medicinal use of bryophytes are sporadic. Despite of a long history of medicinal use of bryophytes by various tr...
Betterment the production of prodigiosin that was produced from Serratia marcescen by means mutations
Serratia marcescens was exposed to mutation for becoming better the production of prodigiosin (quantitatively and qualitatively) and examined it as antibacterial activities. One isolate of S.marcescen (Wild) was exposed...
Factors Affection Degradation of Poly-3-Hydroxybutyrate (Bioplastic) By A Filamentous Bacterium of The Genus Streptomyces
Actinomycetes are filamentous Gram-positive bacteria mostly found in soil and are known as a best producer of antibiotics and useful enzymes. They have important role in the breaking dawn of organic materials and polymer...
Fly ash induced Morphological, Biochemical and Metal accumulation responses at different developmental stages in Glycine max (L.) Merrill. Revised
The research of many previous years has guaranteed the use of fly ash as a material for another green revolution. The present study was channeled to roll up the brilliance of the fly ash in agriculture meticulously. The...
Study of Air quality Status of some cities of Rajasthan
An attempt has been made in this investigation to ascertain air quality on major roads of Ajmer city in the form of Air Quality Index ( AQI). Monitoring stations were set up at fifteen strategic locations on all arterial...