Promising New Target in the Treatment of Diseases: FOXO Transcription Factors
Journal Title: Hippocrates Medical Journal - Year 2022, Vol 2, Issue 1
Abstract
Cells have evolved elaborate mechanisms to survive or coordinate the cellular response to apoptosis. Forkhead box-O transcription factors (FOXOs); It plays critical roles in the execution of various cellular processes by regulating the expression of genes involved in DNA damage repair, cell cycle progression and arrest, oxidative stress response and redox signaling, gluconeogenesis and apoptosis. Function of FOXO transcription factors; It is tightly controlled by post-translational modifications such as phosphorylation, acetylation and ubiquitination, and nuclear cytoplasmic transition. Made works; It shows that the regulatory effect of FOXO activity occurs in response to different stimuli, including oxidative stress. Abnormalities in post-transcriptional modification of FOXO transcription factors are frequently associated with various disease states. In this study; In order to present new research ideas to scientists, the definition and classification of FOXO transcription factors, post-transcriptional FOXO modifications under various physiological and pathophysiological conditions, including oxidative stress and cancer, and the clinical use of FOXO's tumor suppressor properties as therapeutics were investigated and compiled in the light of literature.
Authors and Affiliations
Nihal VURANOK
Keywords
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- EP ID EP708988
- DOI 10.29228/HMJ.11
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