Prophylactic effect of sodium valproate in traumatic brain injury patients with early post-traumatic seizures
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2017, Vol 7, Issue 9
Abstract
Background: Post traumatic seizures has been described as a particularly heterogeneous condition, specifically because of the heterogeneity associated with TBI Epidemiological studies have found that PTS accounts for 10–20% of symptomatic epilepsy in the general population and 5% of all epilepsies. Seizure activity in the early post-traumatic period after head injury may cause secondary brain damage. Prophylaxis for PTS refers to the practice of administering anti convulsants to the patients following head injury to prevent the occurrence of seizures. Aim: The present study was undertaken to evaluate the prevalence of early posttraumatic seizures in TBI and effectiveness of sodium valproate in treating seizures. Materials and Methods: It is an observational study conducted at a private hospital and the information from the medical records and charts of medical investigations of the patients were collected and reviewed. Results: From a total study population of 200, the incidence of ePTS was found to be 12% (24 patients). The most affected age group was between 18-50years (81.5%). The most common cause of traumatic brain injury among the study population was road traffic accident in 152 patients (76%). After treating with sodium valproate, the incidence of ePTS was zero in all patients previously observed with ePTS. Conclusions: The frequency of occurrence of TBI is high among young adults compared to elderly. There are multiple causes for TBI but the most important cause is RTA, among which males are at higher risk of TBI. The incidence of occurrence of early post traumatic seizures was found to be 12% from the study population. Occurrence of PTS is linked to the severity of injury. Use of sodium valproate has reduced the incidence of ePTS in almost all patients.
Authors and Affiliations
Ch. Jyothi, Dr. P. Kishore, Dr. T. Sanjay, Dr. D. Sudheer kumar, R. Deepthi
Keywords
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