Prophylactic Use of Ondansetron for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 3
Abstract
The prophylactic antiemetic efficacy of intravenous ondansetron was evaluated in a prospective randomized, double blind comparison with the placebo in 80 patients undergoing laparoscopic cholecystectomy under general anaesthesia. Patients were randomly allocated to receive ondansetron 8mg (4 ml) or placebo (Normal saline, 4m1) before induction of a standardised general anaesthesia. The incidence of nausea was 60% in placebo and 35% in the ondansetron group (p <0.01). Similarly the incidence of vomiting was 22.5% in the placebo group and 5%' in the ondansetron group (p <0.01). Finally, only 32.5% of the ondansetron treated patients required a rescue antiemetic compared with 57.5% in the placebo group. Thus, in patients undergoing laparoscopic cholecystectomy ondansetron (8mg) before induction of anaesthesia appears to be a promising antiemetic for the prevention of PONV.
Authors and Affiliations
Harbhupinder Singh, Gurlivleen Kaur, Surinder Singh, Dhanwant Kaur
Keywords
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