Prospective clinical study on cardiotoxicity induced by anthracycline on a sample of 29 patients with breast cancer.
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2009, Vol 1, Issue 2
Abstract
Objective: This study is focused on the evaluation of the early and late cardiotoxic effects of chemotherapy with anthracyclines based on conventional electrocardiography, echocardiography transtoracic, and determination of the markers of myocardic, harming and invasive evaluation by endomyocardial punction-biopsy. Material and methods: The sample was formed by female patients with breast cancer, homogenous, the majority of them without preexisting cardiac pathology and without risk factors to develop this. Results and discussion: It was observed that the standard EKG examination is unspecific to detect the first signs of cardio toxicity, modifications appearing tardy to those with certain echocardiography signs or being possible the appearance of some EKG modifications. Concerning the echocardiographic and Doppler examination, the first suggestive modifications for cardiotoxicity were ascertained to the level of diastolic function of LV (left ventricle), but these appeared to a large number of patients and were slightly specific. The decline of the EF (ejection fraction) is the most specific sight of anthracyclines cardiotoxicity, resulting in a dilated cardiomyopathy, with the classic symptoms of cardiac failure. RT, generally with small doses, was associated CT in the majority of cases and did not determined modifications of the parameters of cardiac function.
Authors and Affiliations
Carmen Muresan, Stefan Mot, Svetlana Encica, Remus Campean
Keywords
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